Cloud point extraction of Δ9-tetrahydrocannabinol from cannabis resin

被引：0
作者：
S. Ameur
B. Haddou
Z. Derriche
J. P. Canselier
C. Gourdon
机构：
[1] U. S. T. Oran,Faculté des Sciences, Département de Chimie, Laboratoire de Physico Chimie des Matériaux
[2] UMR 5503,Laboratoire de Génie Chimique
[3] Campus INP-ENSIACET,undefined
来源：
Analytical and Bioanalytical Chemistry | 2013年 / 405卷
关键词：
Cannabis; Δ; -Tetrahydrocannabinol; Cloud point extraction; Coacervate; HPLC; Diode array detector; Nonionic surfactant;
D O I：
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中图分类号：
学科分类号：
摘要：
A cloud point extraction coupled with high performance liquid chromatography (HPLC/UV) method was developed for the determination of Δ9-tetrahydrocannabinol (THC) in micellar phase. The nonionic surfactant “Dowfax 20B102” was used to extract and pre-concentrate THC from cannabis resin, prior to its determination with a HPLC–UV system (diode array detector) with isocratic elution. The parameters and variables affecting the extraction were investigated. Under optimum conditions (1 wt.% Dowfax 20B102, 1 wt.% Na2SO4, T = 318 K, t = 30 min), this method yielded a quite satisfactory recovery rate (~81 %). The limit of detection was 0.04 μg mL−1, and the relative standard deviation was less than 2 %. Compared with conventional solid–liquid extraction, this new method avoids the use of volatile organic solvents, therefore is environmentally safer.
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页码：3117 / 3123
页数：6
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