Synthesis of Some Indolyl Derivatives under Solvent Free Conditions, Their Cytotoxicity, and DNA Cleavage Studies

被引：0
作者：
A. S. Rathod
J. S. Biradar
机构：
[1] Gulbarga University,Central Research Lab, Department of Chemistry
来源：
Russian Journal of General Chemistry | 2020年 / 90卷
关键词：
indole; pyran; dimedone; thiobarbutiric and barbutiric acid; MW-assisted; green synthesis; anticancer activity; DNA cleavage;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A one-pot, rapid, facile, green, and efficient method of synthesis of pyran fused indolyl and 1,3-dicarbonyl analogs has been carried out under the conventional and also solvent-free conditions involving MW irradiation. The structures of products have been confirmed by spectral data. All products have been tested for DNA cleavage and in vitro cytotoxicity against three tumor cell lines. Some products are characterized by high activity.
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页码：135 / 141
页数：6
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