Perilesional edema in brain metastasis from non-small cell lung cancer (NSCLC) as predictor of response to radiosurgery (SRS)

被引:0
作者
Paolo Tini
Valerio Nardone
Pierpaolo Pastina
Giuseppe Battaglia
Claudia Vinciguerra
Tommaso Carfagno
Giovanni Rubino
Salvatore Francesco Carbone
Lucio Sebaste
Alfonso Cerase
Antonio Federico
Luigi Pirtoli
机构
[1] IstitutoToscanoTumori,Unit of Radiation Oncology
[2] University Hospital of Siena,Department of Medicine, Surgery and Neurological Sciences, Research Center for Molecular Radiobiology
[3] University of Siena,Unit of Clinical Neurology and Neurometabolic Disorders, Department of Medical, Surgical and Neurological Sciences
[4] University of Siena,Unit of Diagnostic Radiology
[5] University Hospital of Siena,Unit of Neuroradiology
[6] University Hospital of Siena,undefined
来源
Neurological Sciences | 2017年 / 38卷
关键词
Peritumoral edema; Brain metastases; NSCLC; Stereotactic radiosurgery; Predictor;
D O I
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学科分类号
摘要
Radiosurgery (SRS) is widely used in the treatment of brain oligo-metastases from NSCLC. The aim of present study is to evaluate the extent of perilesional edema in brain metastases as predictive factor of treatment response. This single center retrospective study included 42 consecutive patients (January 2011–December 2014) with 1–2 brain metastasis from NSCLC treated with Radiosurgery (SRS). Extent of perilesional edema was measured as maximal extension from the edge of lesion and classified as minor (<10 mm) or major (≥10 mm). We analyzed Modality of Brain Recurrence (MBR), classified as in-field or out-of- field, and Brain Progression Free-Survival (BPFS) after treatment stratified according to extent of perilesional edema. Analyzing modality of brain recurrence and BPFS, after a median follow-up of 6 months, we found that patients with minor edema had a better radiological response to SRS with none in-field recurrences and a lower risk of the onset of new brain lesions (out-of-field recurrence). Instead, patients group with major edema had a worse response rate of lesions treated, further, a higher risk of out-of-field brain relapse. Extent of perilesional edema in brain metastasis from NSCLC could be a predictive factor of response and brain progression after SRS treatment alone.
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页码:975 / 982
页数:7
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  • [1] Sperduto PW(2012)Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases J Clin Oncol 30 419-425
  • [2] Kased N(2012)Chemotherapy for brain metastases from small cell lung cancer Cochrane Database Syst Rev 6 CD007464-465
  • [3] Roberge D(2012)Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial Lancet Oncol 13 459-83
  • [4] Xu Z(2010)Safety and efficacy of gamma knife surgery for brain metastases in eloquent locations J Neurosurg 113 79-1395
  • [5] Shanley R(2007)Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone Int J Radiat Oncol Biol Phys 68 1388-1044
  • [6] Luo X(2009)Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial Lancet Oncol 10 1037-717
  • [7] Sneed PK(2015)Phase 3 trials of stereotactic radiosurgery with or without whole-brain radiation therapy for 1–4 brain metastases: individual patient data meta-analysis Int J Radiat Oncol Biol Phys 91 710-1398
  • [8] Chao ST(2012)Treatment of five or more brain metastases with stereotactic radiosurgery Int J Radiat Oncol Biol Phys 83 1394-490
  • [9] Weil RJ(2013)Survival and intracranial control of patients with five or more brain metastases treated with gamma knife stereotactic radiosurgery Am J Clin Oncol 36 486-193
  • [10] Suh J(2013)Role of stereotactic radiosurgery in patients with more than four brain metastases CNS oncol 2 181-878