Panallergens and their impact on the allergic patient

被引：234
作者：
Hauser M. [1 ]
Roulias A. [1 ]
Ferreira F. [1 ]
Egger M. [1 ]
机构：
[1] Christian Doppler Laboratory for Allergy Diagnosis and Therapy, Department of Molecular Biology, University of Salzburg, A-5020 Salzburg
来源：
Allergy, Asthma & Clinical Immunology | / 6卷 / 1期
关键词：
Food Allergy; Major Allergen; Allergen Source; Allergenic Molecule; Minor Allergen;
D O I：
10.1186/1710-1492-6-1
中图分类号：
学科分类号：
摘要：
The panallergen concept encompasses families of related proteins, which are involved in general vital processes and thus, widely distributed throughout nature. Plant panallergens share highly conserved sequence regions, structure, and function. They are responsible for many IgE cross-reactions even between unrelated pollen and plant food allergen sources. Although usually considered as minor allergens, sensitization to panallergens might be problematic as it bears the risk of developing multiple sensitizations. Clinical manifestations seem to be tightly connected with geographical and exposure factors. Future population- and disease-based screenings should provide new insights on panallergens and their contribution to disease manifestations. Such information requires molecule-based diagnostics and will be valuable for developing patient-tailored prophylactic and therapeutic approaches. In this article, we focus on profilins, non-specific lipid transfer proteins, polcalcins, and Bet v 1-related proteins and discuss possible consequences of panallergen sensitization for the allergic patient. Based on their pattern of IgE cross-reactivity, which is reflected by their distribution in the plant kingdom, we propose a novel classification of panallergens into ubiquitously spread "real panallergens" (e.g. profilins) and widespread "eurallergens" (e.g. polcalcins). "Stenallergens" display more limited distribution and cross-reactivity patterns, and "monallergens" are restricted to a single allergen source. © 2010 Hauser et al; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 82 条
  • [1] Mothes N., Horak F., Valenta R., Transition from a botanical to a molecular classification in tree pollen allergy: implications for diagnosis and therapy, Int Arch Allergy Immunol, 135, pp. 357-373, (2004)
  • [2] Burastero S.E., Pollen-cross allergenicity mediated by panallergens: a clue to the patho-genesis of multiple sensitizations, Inflamm Allergy Drug Targets, 5, pp. 203-209, (2006)
  • [3] Ballmer-Weber B.K., Vieths S., Soy allergy in perspective, Curr Opin Allergy Clin Immunol, 8, pp. 270-275, (2008)
  • [4] Hauser M., Egger M., Wallner M., Wopfner N., Schmidt G., Ferreira F., Molecular properties of plant food allergens: a current classification into protein families, The Open Immunology Journal, 1, pp. 1-12, (2008)
  • [5] Mittag D., Akkerdaas J., Ballmer-Weber B.K., Vogel L., Wensing M., Becker W.M., Koppelman S.J., Knulst A.C., Helbling A., Hefle S.L., Van Ree R., Vieths S., Ara h 8, a Bet v 1-homologous allergen from peanut, is a major allergen in patients with combined birch pollen and peanut allergy, J Allergy Clin Immunol, 114, pp. 1410-1417, (2004)
  • [6] Mari A., Multiple pollen sensitization: a molecular approach to the diagnosis, Int Arch Allergy Immunol, 125, pp. 57-65, (2001)
  • [7] Asero R., Monsalve R., Barber D., Profilin sensitization detected in the office by skin prick test: a study of prevalence and clinical relevance of profilin as a plant food allergen, Clin Exp Allergy, 38, pp. 1033-1037, (2008)
  • [8] Dubost R., Ruet N., Deviller P., [Incidence of sensitization to profilin in a population allergic to pollen: responsibility of profilin in pollen polysensitizations in patients with a normal level of total IgE], Allerg Immunol (Paris), 32, pp. 199-206, (2000)
  • [9] Wopfner N., Willeroidee M., Hebenstreit D., van Ree R., Aalbers M., Briza P., Thalhamer J., Ebner C., Richter K., Ferreira F., Molecular and immunological characterization of profilin from mugwort pollen, Biol Chem, 383, pp. 1779-1789, (2002)
  • [10] Burastero S.E., Paolucci C., Breda D., Longhi R., Silvestri M., Hammer J., Protti M.P., Rossi G.A., T-cell receptor-mediated cross-allergenicity, Int Arch Allergy Immunol, 135, pp. 296-305, (2004)
123456789