Diagnostic performance of 18F-dihydroxyphenylalanine positron emission tomography in patients with paraganglioma: a meta-analysis

被引：86

作者：

Treglia, Giorgio ^{[1
]}

Cocciolillo, Fabrizio ^{[1
]}

de Waure, Chiara ^{[2
]}

Di Nardo, Francesco ^{[2
]}

Gualano, Maria Rosaria ^{[2
]}

Castaldi, Paola ^{[1
]}

Rufini, Vittoria ^{[1
]}

Giordano, Alessandro ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Inst Nucl Med, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Inst Hyg, I-00168 Rome, Italy

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2012年 / 39卷 / 07期

关键词：

Positron emission tomography; PET/CT; F-18-Dihydroxyphenylalanine; Paraganglioma; Phaeochromocytoma; NEUROENDOCRINE TUMORS; NECK PARAGANGLIOMAS; PET; PHEOCHROMOCYTOMA; LOCALIZATION; SCINTIGRAPHY; F-18-FDOPA; EXPERIENCE; MUTATIONS; HEAD;

D O I：

10.1007/s00259-012-2087-y

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose The aim of this study was to systematically review and conduct a meta-analysis of published data about the diagnostic performance of F-18-dihydroxyphenylalanine (DOPA) positron emission tomography (PET) in patients with paraganglioma (PG). Methods A comprehensive computer literature search of studies published through 30 June 2011 regarding F-18-DOPA PET or PET/computed tomography (PET/CT) in patients with PG was performed in PubMed/MEDLINE, Embase and Scopus databases. Pooled sensitivity and specificity of F-18-DOPA PET or PET/CT in patients with PG on a per patient- and on a per lesion-based analysis were calculated. The area under the receiver-operating characteristic (ROC) curve was calculated to measure the accuracy of F-18-DOPA PET or PET/CT in patients with PG. Furthermore, a sub-analysis taking into account the different genetic mutations in PG patients was also performed. Results Eleven studies comprising 275 patients with suspected PG were included in this meta-analysis. The pooled sensitivity of F-18-DOPA PET and PET/CT in detecting PG was 91% [95% confidence interval (CI) 87-94%] on a per patient-based analysis and 79% (95% CI 76-81%) on a per lesion-based analysis. The pooled specificity of F-18-DOPA PET and PET/CT in detecting PG was 95% (95% CI 86-99%) on a per patient-based analysis and 95% (95% CI 84-99%) on a per lesion-based analysis. The area under the ROC curve was 0.95 on a per patient- and 0.94 on a per lesion-based analysis. Heterogeneity between the studies about sensitivity of F-18-DOPA PET or PET/CT was found. A significant increase in sensitivity of F-18-DOPA PET or PET/CT was observed when a sub-analysis excluding patients with succinate dehydrogenase subunit B (SDHB) gene mutations was performed. Conclusions In patients with suspected PG F-18-DOPA PET or PET/CT demonstrated high sensitivity and specificity. F-18-DOPA PET or PET/CT are accurate methods in this setting. Nevertheless, possible sources of false-negative results should be kept in mind. Furthermore, SDHB gene mutations could influence F-18-DOPA PET or PET/CT diagnostic performance.

引用

页码：1144 / 1153

页数：10

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