Bcl-2-regulated cell death signalling in the prevention of autoimmunity.

被引：77
作者：
Tischner D. [1 ]
Woess C. [1 ]
Ottina E. [1 ]
Villunger A. [1 ]
机构：
[1] Division of Developmental Immunology, BIOCENTER, Medical University Innsbruck, Innsbruck
来源：
Cell Death & Disease | 2010年 / 1卷 / 6期
基金：
奥地利科学基金会;
关键词：
apoptosis; Bcl-2 family; BH3-only proteins; autoimmunity;
D O I：
10.1038/cddis.2010.27
中图分类号：
学科分类号：
摘要：
Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling pathway is critical for lymphocyte development and the establishment of central and maintenance of peripheral tolerance. Defects in Bcl-2-regulated cell death signalling have been reported to cause or correlate with autoimmunity in mice and men. This review focuses on the role of Bcl-2 family proteins implicated in the development of autoimmune disorders and their potential as targets for therapeutic intervention.
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收藏
页码：e48 / e48
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