Safety and Efficacy of miltefosine alone and in combination with sodium stibogluconate and liposomal amphotericin B for the treatment of primary visceral leishmaniasis in East Africa: study protocol for a randomized controlled trial

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作者
Raymond Omollo
Neal Alexander
Tansy Edwards
Eltahir AG Khalil
Brima M Younis
Abuzaid A Abuzaid
Monique Wasunna
Njenga Njoroge
Dedan Kinoti
George Kirigi
Thomas PC Dorlo
Sally Ellis
Manica Balasegaram
Ahmed M Musa
机构
[1] Kenya Medical Research Institute,Drugs for Neglected Diseases initiative (DNDi) Africa, Centre for Clinical Research
[2] London School of Hygiene and Tropical Medicine,MRC Tropical Epidemiology Group
[3] University of Khartoum,Institute of Endemic Diseases
[4] Kenya Medical Research Institute,Centre for Clinical Research
[5] Academic Medical Center,Division of Infectious Diseases, Tropical Medicine & AIDS
[6] Slotervaart Hospital,Department of Pharmacy & Pharmacology
[7] DNDi,undefined
来源
Trials | / 12卷
关键词
Visceral Leishmaniasis; Miltefosine; AmBisome; Tri-angular test; protocol; RCT;
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[1]  
Desjeux P(1996)Leishmaniasis. Public health aspects and control Clin Dermatol 14 417-423
[2]  
Zijlstra EE(2003)Post-kala-azar dermal leishmaniasis Lancet Infect Dis 3 87-98
[3]  
Musa AM(2010)Geographical variation in the response of visceral leishmaniasis to paromomycin in East Africa: a multicentre, open-label, randomized trial PLoS Negl Trop Dis 4 e709-194
[4]  
Khalil EA(2010)Paromomycin for the treatment of visceral leishmaniasis in Sudan: a randomized, open-label, dose-finding study PLoS Negl Trop Dis 4 e855-364
[5]  
el-Hassan IM(2010)Combination therapy for visceral leishmaniasis Lancet Infect Dis 10 184-598
[6]  
el-Hassan AM(2006)A comparison of miltefosine and sodium stibogluconate for treatment of visceral leishmaniasis in an Ethiopian population with high prevalence of HIV infection Clin Infect Dis 43 357-1746
[7]  
Hailu A(2007)Phase 4 trial of miltefosine for the treatment of Indian visceral leishmaniasis J Infect Dis 196 591-486
[8]  
Musa A(2002)Oral miltefosine for Indian visceral leishmaniasis N Engl J Med 347 1739-917
[9]  
Wasunna M(2011)Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomised controlled trial Lancet 377 477-2860
[10]  
Balasegaram M(2002)Triangular test applied to the clinical trial of azithromycin against relapses in Plasmodium vivax infections Malar J 1 13-62