Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies

被引：125

作者：

Dyall J. ^{[1
]}

Gross R. ^{[1
]}

Kindrachuk J. ^{[2
]}

Johnson R.F. ^{[3
]}

Olinger G.G., Jr. ^{[4
]}

Hensley L.E. ^{[1
]}

Frieman M.B. ^{[5
]}

Jahrling P.B. ^{[1
,3
]}

机构：

[1] Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD

[2] Department of Medical Microbiology, University of Manitoba, Winnipeg, MN

[3] Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD

[4] University of Boston, Boston, MA

[5] Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD

来源：

Drugs | 2017年 / 77卷 / 18期

关键词：

D O I：

10.1007/s40265-017-0830-1

中图分类号：

学科分类号：

摘要：

No specific antivirals are currently available for two emerging infectious diseases, Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). A literature search was performed covering pathogenesis, clinical features and therapeutics, clinically developed drugs for repurposing and novel drug targets. This review presents current knowledge on the epidemiology, pathogenesis and clinical features of the SARS and MERS coronaviruses. The rationale for and outcomes with treatments used for SARS and MERS is discussed. The main focus of the review is on drug development and the potential that drugs approved for other indications provide for repurposing. The drugs we discuss belong to a wide range of different drug classes, such as cancer therapeutics, antipsychotics, and antimalarials. In addition to their activity against MERS and SARS coronaviruses, many of these approved drugs have broad-spectrum potential and have already been in clinical use for treating other viral infections. A wealth of knowledge is available for these drugs. However, the information in this review is not meant to guide clinical decisions, and any therapeutic described here should only be used in context of a clinical trial. Potential targets for novel antivirals and antibodies are discussed as well as lessons learned from treatment development for other RNA viruses. The article concludes with a discussion of the gaps in our knowledge and areas for future research on emerging coronaviruses. © 2017, Springer International Publishing AG.

引用

页码：1935 / 1966

页数：31

共 164 条

[11]

Adney D.R., van Doremalen N., Brown V.R., Bushmaker T., Scott D., de Wit E., Et al., Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels, Emerg Infect Dis., 20, 12, pp. 1999-2005, (2014)

[12]

Wang L.F., Shi Z., Zhang S., Field H., Daszak P., Eaton B.T., Review of bats and SARS, Emerg Infect Dis., 12, 12, pp. 1834-1840, (2006)

[13]

Chowell G., Abdirizak F., Lee S., Lee J., Jung E., Nishiura H., Et al., Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study, BMC Med., 13, (2015)

[14]

Hunter J.C., Nguyen D., Aden B., Al Bandar Z., Al Dhaheri W., Abu Elkheir K., Et al., Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings, Abu Dhabi, Emerg Infect Dis., 22, 4, pp. 647-656, (2016)

[15]

Zumla A., Hui D.S., Perlman S., Middle East respiratory syndrome, Lancet., 386, 9997, pp. 995-1007, (2015)

[16]

Rasmussen S.A., Watson A.K., Swerdlow A.L., Middle East respiratory syndrome (MERS), Microbiol Spectr, 4, 3, pp. 1-23, (2016)

[17]

Chan P.K., Tang J.W., Hui D.S., SARS: clinical presentation, transmission, pathogenesis and treatment options, Clin Sci (Lond)., 110, 2, pp. 193-204, (2006)

[18]

Zaki A.M., van Boheemen S., Bestebroer T.M., Osterhaus A.D., Fouchier R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia, N Engl J Med., 367, 19, pp. 1814-1820, (2012)

[19]

Guery B., Poissy J., el Mansouf L., Sejourne C., Ettahar N., Lemaire X., Et al., Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission, Lancet., 381, 9885, pp. 2265-2272, (2013)

[20]

State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans, PLoS Curr, (2013)

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