A pilot study evaluating sodium hyaluronate as a carrier for freeze-dried demineralized bone powder

被引：10

作者：

Gertzman A.A. ^{[1
]}

Hae Sunwoo M. ^{[1
]}

机构：

[1] Musculoskeletal Transplant Foundation, Research and Development Division, Edison

来源：

Cell and Tissue Banking | 2001年 / 2卷 / 2期

关键词：

Bony defect filler; Demineralized bone matrix; Sodium hyaluronate;

D O I：

10.1023/A:1014398514168

中图分类号：

学科分类号：

摘要：

Freeze-dried demineralized bone (FDDB) is widely used in orthopaedic and neurosurgery. However, it is difficult to deliver the FDDB by itself and surgeons have been seeking a convenient and easy-to-use form of FDDB. This study was designed to evaluate sodium hyaluronate (HA) as a carrier or delivery vehicle. HA is a viscous and biocompatible high molecular weight hydrogel. It was tested as a viscous carrier to facilitate the delivery of freeze-dried demineralized bone into a bony defect. The natural bone forming properties of FDDB were evaluated in an athymic mouse model and shown to be as active when dispersed in HA as compared to a saline control. Particle sizes in the range studied (125-850 μm) had no effect on FDDB efficacy. All exhibited active bone formation. Similarly, two different carrier viscosities were formulated to achieve both a malleable putty and a more flowable paste. These, too, both exhibited active bone formation. The use of pH 7.4 buffer in the HA formulation gave optimum results in the model. Additional studies are underway to further evaluate the surgical efficacy of FDDB suspended in HA.

引用

页码：87 / 94

页数：7

共 8 条

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