Synthesis and biological evaluation of resveratrol–coumarin hybrid compounds as potential antitumor agents

被引：0
作者：
Wei Shen
Jianfeng Mao
Juan Sun
Minjie Sun
Can Zhang
机构：
[1] China Pharmaceutical University,Center for Drug Discovery, School of Pharmacy
[2] China Pharmaceutical University,Department of Pharmaceutics, School of Pharmacy
来源：
Medicinal Chemistry Research | 2013年 / 22卷
关键词：
Resveratrol; Coumarin; Wittig reaction; Perkin reaction; Antitumor activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Eighteen resveratrol–coumarin hybrid compounds (6 or 7-styryl-3-phenylcoumarin) were designed, synthesized and thirteen compounds were evaluated for their antitumor activities against MCF-7, HCT-28, and K562 tumor cell lines. Among them, compounds 2Z, 2E, 5E, and 7E showed varying degrees of growth inhibition of the above cell lines (IC50: 3.78–19.16 μmol/L). On the basis of the biological results, structure–activity relationships were obtained and discussed.
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页码：1630 / 1640
页数：10
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