Antiphospholipid antibodies in critically ill COVID-19 patients with thromboembolism: cause of disease or epiphenomenon?

被引：0
作者：
Vittorio Pavoni
Lara Gianesello
Andrew Horton
机构：
[1] Santa Maria Annunziata Hospital,Emergency Department and Critical Care Area, Anesthesia and Intensive Care Unit
[2] University-Hospital Careggi,Department of Anesthesia and Intensive Care, Orthopedic Anesthesia
[3] University of Utah Health,School of Dentistry
来源：
Journal of Thrombosis and Thrombolysis | 2021年 / 52卷
关键词：
COVID-19; Critically ill patients; Venous thromboembolism; Arterial thromboembolism; Antiphospholipid antibodies; Antiphospholipid antibodies syndrome;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Coronavirus 2019 disease (COVID-19) is associated with coagulation dysfunction that predisposes patients to an increased risk for both arterial (ATE) and venous thromboembolism (VTE) and consequent poor prognosis; in particular, the incidence of ATE and VTE in critically ill COVID-19 patients can reach 5% and 31%, respectively. The mechanism of thrombosis in COVID-19 patients is complex and still not completely clear. Recent literature suggests a link between the presence of antiphospholipid antibodies (aPLs) and thromboembolism in COVID-19 patients. However, it remains uncertain whether aPLs are an epiphenomenon or are involved in the pathogenesis of the disease.
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页码：542 / 552
页数：10
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