Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement

被引：0
作者：
Di Huang
Shanshan Li
Menglei Xia
Jianping Wen
Xiaoqiang Jia
机构：
[1] Tianjin University,Department of Biochemical Engineering, School of Chemical Engineering and Technology
[2] Ministry of Education,TEDA School of Biological Sciences and Biotechnology
[3] Key Laboratory of Systems Bioengineering,undefined
[4] Nankai University,undefined
[5] TEDA,undefined
来源：
Microbial Cell Factories | / 12卷
关键词：
FK506; Genome-scale metabolic model; Target prediction; Metabolic engineering; Combinatorial modification;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [41] dRNA-seq transcriptional profiling of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis NRRL18488 and general analysis of the transcriptome
    Bauer, Judith S.
    Fillinger, Sven
    Foerstner, Konrad
    Herbig, Alexander
    Jones, Adam C.
    Flinspach, Katrin
    Sharma, Cynthia
    Gross, Harald
    Nieselt, Kay
    Apel, Alexander K.
    RNA BIOLOGY, 2017, 14 (11) : 1617 - 1626
  • [42] Systems metabolic engineering: Genome-scale models and beyond
    Blazeck, John
    Alper, Hal
    BIOTECHNOLOGY JOURNAL, 2010, 5 (07) : 647 - 659
  • [43] Genome-scale metabolic model led engineering of Nothapodytes nimmoniana plant cells for high camptothecin production
    Murali, Sarayu
    Ibrahim, Maziya
    Rajendran, Hemalatha
    Shagun, Shagun
    Masakapalli, Shyam Kumar
    Raman, Karthik
    Srivastava, Smita
    FRONTIERS IN PLANT SCIENCE, 2023, 14
  • [44] Genome-scale modeling enables metabolic engineering of Saccharomyces cerevisiae for succinic acid production
    Agren, Rasmus
    Otero, Jose Manuel
    Nielsen, Jens
    JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2013, 40 (07) : 735 - 747
  • [45] Genome-scale metabolic network models for industrial microorganisms metabolic engineering: Current advances and future prospects
    Gong, Zhijin
    Chen, Jiayao
    Jiao, Xinyu
    Gong, Hao
    Pan, Danzi
    Liu, Lingli
    Zhang, Yang
    Tan, Tianwei
    BIOTECHNOLOGY ADVANCES, 2024, 72
  • [46] Improvement of FK506 Production in the High-Yielding Strain Streptomyces sp RM7011 by Engineering the Supply of Allylmalonyl-CoA Through a Combination of Genetic and Chemical Approach
    Mo, SangJoon
    Lee, Sung-Kwon
    Jin, Ying-Yu
    Suh, Joo-Won
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2016, 26 (02) : 233 - 240
  • [47] Genome-scale metabolic flux analysis of Streptomyces lividans growing on a complex medium
    D'Huys, Pieter-Jan
    Lule, Ivan
    Vercammen, Dominique
    Anne, Jozef
    Van Impe, Jan F.
    Bernaerts, Kristel
    JOURNAL OF BIOTECHNOLOGY, 2012, 161 (01) : 1 - 13
  • [48] Identifying metabolic features and engineering targets for productivity improvement in CHO cells by integrated transcriptomics and genome-scale metabolic model
    Huang, Zhuangrong
    Yoon, Seongkyu
    BIOCHEMICAL ENGINEERING JOURNAL, 2020, 159
  • [49] In silico identification of metabolic engineering strategies for improved lipid production in Yarrowia lipolytica by genome-scale metabolic modeling
    Kim, Minsuk
    Park, Beom Gi
    Kim, Eun-Jung
    Kim, Joonwon
    Kim, Byung-Gee
    BIOTECHNOLOGY FOR BIOFUELS, 2019, 12 : 1 - 14
  • [50] In silico identification of metabolic engineering strategies for improved lipid production in Yarrowia lipolytica by genome-scale metabolic modeling
    Minsuk Kim
    Beom Gi Park
    Eun-Jung Kim
    Joonwon Kim
    Byung-Gee Kim
    Biotechnology for Biofuels, 12
12345