NAVIGATOR: a phase 3 multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of tezepelumab in adults and adolescents with severe, uncontrolled asthma

被引：0

作者：

Andrew Menzies-Gow

Gene Colice

Janet M. Griffiths

Gun Almqvist

Sandhia Ponnarambil

Primal Kaur

Gennaro Ruberto

Karin Bowen

Åsa Hellqvist

May Mo

Esther Garcia Gil

机构：

[1] Royal Brompton Hospital,Late Respiratory & Immunology

[2] BioPharmaceuticals R&D,Translational Science and Experimental Medicine, Early Respiratory & Immunology

[3] AstraZeneca,Late Respiratory & Immunology

[4] BioPharmaceuticals R&D,Late Respiratory & Immunology

[5] AstraZeneca,BioPharma Study Management, Late Respiratory & Immunology

[6] BioPharmaceuticals R&D,Biometrics, Late Respiratory & Immunology

[7] AstraZeneca,Biometrics, Late Respiratory & Immunology

[8] BioPharmaceuticals R&D,Global Medical Respiratory

[9] AstraZeneca,undefined

[10] Amgen,undefined

[11] BioPharmaceuticals R&D,undefined

[12] AstraZeneca,undefined

[13] BioPharmaceuticals R&D,undefined

[14] AstraZeneca,undefined

[15] BioPharmaceuticals R&D,undefined

[16] AstraZeneca,undefined

[17] BioPharmaceuticals Medical,undefined

[18] AstraZeneca,undefined

来源：

Respiratory Research | / 21卷

关键词：

Clinical trial; Severe asthma; Tezepelumab; Thymic stromal lymphopoietin;

D O I：

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摘要：

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[1] NAVIGATOR: a phase 3 multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of tezepelumab in adults and adolescents with severe, uncontrolled asthma
Menzies-Gow, Andrew
Colice, Gene
Griffiths, Janet M.
Almqvist, Gun
Ponnarambil, Sandhia
Kaur, Primal
Ruberto, Gennaro
Bowen, Karin
Hellqvist, Asa
Mo, May
Garcia Gil, Esther
RESPIRATORY RESEARCH, 2020, 21 (01)
[2] DESTINATION: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe, uncontrolled asthma
Andrew Menzies-Gow
Sandhia Ponnarambil
John Downie
Karin Bowen
Åsa Hellqvist
Gene Colice
Respiratory Research, 21
[3] DESTINATION: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe, uncontrolled asthma
Menzies-Gow, Andrew
Ponnarambil, Sandhia
Downie, John
Bowen, Karin
Hellqvist, Asa
Colice, Gene
RESPIRATORY RESEARCH, 2020, 21 (01)
[4] CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma
Claire Emson
Sarah Diver
Latifa Chachi
Ayman Megally
Cherrie Small
John Downie
Jane R. Parnes
Karin Bowen
Gene Colice
Chris E. Brightling
Respiratory Research, 21
[5] CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma
Emson, Claire
Diver, Sarah
Chachi, Latifa
Megally, Ayman
Small, Cherrie
Downie, John
Parnes, Jane R.
Bowen, Karin
Colice, Gene
Brightling, Chris E.
RESPIRATORY RESEARCH, 2020, 21 (01)
[6] A randomized, double-blind, parallel-group, placebo-controlled Phase 3 trial to evaluate efficacy and safety of ocrelizumab in PPMS
Montalban, Xavier
Hemmer, Bernhard
Rammohan, Kottil W.
Giovannoni, Gavin
De Seze, Jerome
Bar-Or, Amit
Arnold, Douglas L.
Sauter, Annette
Masterman, Donna
Fontoura, Paulo
Chin, Peter
Garren, Hideki
Wolinsky, Jerry S.
MULTIPLE SCLEROSIS JOURNAL, 2016, 22 : 17 - 17
[7] Liberty Asthma QUEST: Phase 3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate Dupilumab Efficacy/Safety in Patients with Uncontrolled, Moderate-to-Severe Asthma
Busse, William W.
Maspero, Jorge F.
Rabe, Klaus F.
Papi, Alberto
Wenzel, Sally E.
Ford, Linda B.
Pavord, Ian D.
Zhang, Bingzhi
Staudinger, Heribert
Pirozzi, Gianluca
Amin, Nikhil
Akinlade, Bolanle
Eckert, Laurent
Chao, Jingdong
Graham, Neil M. H.
Teper, Ariel
ADVANCES IN THERAPY, 2018, 35 (05) : 737 - 748
[8] Liberty Asthma QUEST: Phase 3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate Dupilumab Efficacy/Safety in Patients with Uncontrolled, Moderate-to-Severe Asthma
William W. Busse
Jorge F. Maspero
Klaus F. Rabe
Alberto Papi
Sally E. Wenzel
Linda B. Ford
Ian D. Pavord
Bingzhi Zhang
Heribert Staudinger
Gianluca Pirozzi
Nikhil Amin
Bolanle Akinlade
Laurent Eckert
Jingdong Chao
Neil M. H. Graham
Ariel Teper
Advances in Therapy, 2018, 35 : 737 - 748
[9] SOURCE: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of tezepelumab in reducing oral corticosteroid use in adults with oral corticosteroid dependent asthma
Wechsler, Michael E.
Colice, Gene
Griffiths, Janet M.
Almqvist, Gun
Skarby, Tor
Piechowiak, Teresa
Kaur, Primal
Bowen, Karin
Hellqvist, Asa
Mo, May
Garcia Gil, Esther
RESPIRATORY RESEARCH, 2020, 21 (01)
[10] SOURCE: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of tezepelumab in reducing oral corticosteroid use in adults with oral corticosteroid dependent asthma
Michael E. Wechsler
Gene Colice
Janet M. Griffiths
Gun Almqvist
Tor Skärby
Teresa Piechowiak
Primal Kaur
Karin Bowen
Åsa Hellqvist
May Mo
Esther Garcia Gil
Respiratory Research, 21

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