NAVIGATOR: a phase 3 multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of tezepelumab in adults and adolescents with severe, uncontrolled asthma

被引：0

作者：

Andrew Menzies-Gow

Gene Colice

Janet M. Griffiths

Gun Almqvist

Sandhia Ponnarambil

Primal Kaur

Gennaro Ruberto

Karin Bowen

Åsa Hellqvist

May Mo

Esther Garcia Gil

机构：

[1] Royal Brompton Hospital,Late Respiratory & Immunology

[2] BioPharmaceuticals R&D,Translational Science and Experimental Medicine, Early Respiratory & Immunology

[3] AstraZeneca,Late Respiratory & Immunology

[4] BioPharmaceuticals R&D,Late Respiratory & Immunology

[5] AstraZeneca,BioPharma Study Management, Late Respiratory & Immunology

[6] BioPharmaceuticals R&D,Biometrics, Late Respiratory & Immunology

[7] AstraZeneca,Biometrics, Late Respiratory & Immunology

[8] BioPharmaceuticals R&D,Global Medical Respiratory

[9] AstraZeneca,undefined

[10] Amgen,undefined

[11] BioPharmaceuticals R&D,undefined

[12] AstraZeneca,undefined

[13] BioPharmaceuticals R&D,undefined

[14] AstraZeneca,undefined

[15] BioPharmaceuticals R&D,undefined

[16] AstraZeneca,undefined

[17] BioPharmaceuticals Medical,undefined

[18] AstraZeneca,undefined

来源：

Respiratory Research | / 21卷

关键词：

Clinical trial; Severe asthma; Tezepelumab; Thymic stromal lymphopoietin;

D O I：

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摘要：

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[1] NAVIGATOR: a phase 3 multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of tezepelumab in adults and adolescents with severe, uncontrolled asthma
Menzies-Gow, Andrew
Colice, Gene
Griffiths, Janet M.
Almqvist, Gun
Ponnarambil, Sandhia
Kaur, Primal
Ruberto, Gennaro
Bowen, Karin
Hellqvist, Asa
Mo, May
Garcia Gil, Esther
RESPIRATORY RESEARCH, 2020, 21 (01)
[2] DESTINATION: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe, uncontrolled asthma
Menzies-Gow, Andrew
Ponnarambil, Sandhia
Downie, John
Bowen, Karin
Hellqvist, Asa
Colice, Gene
RESPIRATORY RESEARCH, 2020, 21 (01)
[3] DESTINATION: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe, uncontrolled asthma
Andrew Menzies-Gow
Sandhia Ponnarambil
John Downie
Karin Bowen
Åsa Hellqvist
Gene Colice
Respiratory Research, 21
[4] CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma
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Diver, Sarah
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Brightling, Chris E.
RESPIRATORY RESEARCH, 2020, 21 (01)
[5] CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma
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[6] SOURCE: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of tezepelumab in reducing oral corticosteroid use in adults with oral corticosteroid dependent asthma
Wechsler, Michael E.
Colice, Gene
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RESPIRATORY RESEARCH, 2020, 21 (01)
[7] SOURCE: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of tezepelumab in reducing oral corticosteroid use in adults with oral corticosteroid dependent asthma
Michael E. Wechsler
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Respiratory Research, 21
[8] Phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group study of ustekinumab in patients with Takayasu arteritis
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RHEUMATOLOGY ADVANCES IN PRACTICE, 2025, 9 (02)
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RHEUMATOLOGY AND THERAPY, 2020, 7 (04) : 793 - 810
[10] A Multicentre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Sirukumab in the Treatment of Giant Cell Arteritis
Wolfgang A. Schmidt
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Rheumatology and Therapy, 2020, 7 : 793 - 810

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