Activation and Coreceptor Expression of T Lymphocytes in HIV/AIDS Patients of China

被引：0
作者：
Hong Shang
Zining Zhang
Yongjun Jiang
Xiaoxu Han
Yanan Wang
Min Zhang
Xiaohui Ye
Ying Liu
Yingying Diao
Di Dai
Wenqing Geng
机构：
[1] AIDS Research Center,
[2] the First Affiliated Hospital,undefined
[3] China Medical University,undefined
[4] AIDS Research Center,undefined
[5] the First Affiliated Hospital,undefined
[6] China Medical University,undefined
来源：
Journal of Clinical Immunology | 2005年 / 25卷
关键词：
HIV-1; activation; HLA-DR; CD38; coreceptor; CCR5; CXCR4;
D O I：
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中图分类号：
学科分类号：
摘要：
The objective of this paper was to investigate the activation and coreceptor CCR5, CXCR4 expression of T lymphocytes in HIV/AIDS patients of China, and to study their association with disease progression. Seventy-seven HIV/AIDS patients and thirteen normal controls were enrolled and three-color flow-cytometry was used to detect the activation marker HLA-DR, CD38 and the coreceptor CCR5, CXCR4 expression on T lymphocytes in whole blood samples taken from the patients and the controls. The HLA-DR, CD38 and CCR5 expression on CD4, CD8+ T cells in AIDS patients was higher than in asymptomatic HIV-1 infected patients and normal controls (p < 0.05); The activation and CCR5 expression on T lymphocytes significantly correlated with CD4+ T lymphocyte number and viral load. The activation on T lymphocytes and the expression of CCR5 on T lymphocytes in HIV/AIDS patients of China are significantly correlated with disease progression.
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页码：68 / 72
页数：4
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