Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl− efflux signaling pathway

[1] Pap T(2015)Cartilage damage in osteoarthritis and rheumatoid arthritis–two unequal siblings Nat Rev Rheumatol 11 606-615

[2] Korb-Pap A(2021)Cell-cell interactions in joint pain: rheumatoid arthritis and osteoarthritis Pain 162 714-717

[3] Pattison LA(2016)Direct in vivo evidence of activated macrophages in human osteoarthritis Osteoarthritis Cartilage 24 1613-21

[4] Kraus VB(2018)Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation Ann Rheum Dis 77 1053-1062

[5] Zeisbrich M(2018)Metabolic regulation of NLRP3 Immunol Rev 281 88-98

[6] Hughes MM(2016)Mechanism and regulation of NLRP3 inflammasome activation Trends Biochem Sci 41 1012-1021

[7] O’Neill LAJ(2016)The overexpression of NALP3 inflammasome in knee osteoarthritis is associated with synovial membrane prolidase and NADPH Oxidase 2 Oxid Med Cell Longev 2016 1472567-243

[8] He Y(2018)NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis Clin Exp Immunol 194 231-619

[9] Hara H(2018)NLRP3 as a potentially novel biomarker for the management of osteoarthritis Osteoarthritis Cartilage 26 612-652

[10] Núñez G(2012)Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases Nat Rev Drug Discov 11 633-1298

[1] Pap T(2015)Cartilage damage in osteoarthritis and rheumatoid arthritis–two unequal siblings Nat Rev Rheumatol 11 606-615

[2] Korb-Pap A(2021)Cell-cell interactions in joint pain: rheumatoid arthritis and osteoarthritis Pain 162 714-717

[3] Pattison LA(2016)Direct in vivo evidence of activated macrophages in human osteoarthritis Osteoarthritis Cartilage 24 1613-21

[4] Kraus VB(2018)Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation Ann Rheum Dis 77 1053-1062

[5] Zeisbrich M(2018)Metabolic regulation of NLRP3 Immunol Rev 281 88-98

[6] Hughes MM(2016)Mechanism and regulation of NLRP3 inflammasome activation Trends Biochem Sci 41 1012-1021

[7] O’Neill LAJ(2016)The overexpression of NALP3 inflammasome in knee osteoarthritis is associated with synovial membrane prolidase and NADPH Oxidase 2 Oxid Med Cell Longev 2016 1472567-243

[8] He Y(2018)NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis Clin Exp Immunol 194 231-619

[9] Hara H(2018)NLRP3 as a potentially novel biomarker for the management of osteoarthritis Osteoarthritis Cartilage 26 612-652

[10] Núñez G(2012)Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases Nat Rev Drug Discov 11 633-1298