Single-atom nanozymes towards central nervous system diseases

被引:0
作者
Weichen Wei
机构
[1] University of California San Diego,Department of Nanoengineering
来源
Nano Research | 2023年 / 16卷
关键词
single-atom nanozymes; single-atom catalysis; central nervous system diseases; enzyme-like catalysts; reactive oxygen species;
D O I
暂无
中图分类号
学科分类号
摘要
Nanozymes have a similar catalytic mechanism to natural enzymes, with excellent performance, facile synthesis, and better stability. Single-atom nanozymes are developed based on single-atom catalysts due to their advantages in coordination structure and electronic configuration, making them highly enzymatic-like biomimetic catalysts. Central nervous system (CNS) diseases have become one of the biggest killers of human health because they are difficult to diagnose and treat, expensive, and result in serious illness. Single-atom nanozymes have been widely used for biomedical applications, especially in oxidative-stress-induced diseases and most CNS diseases which are closely related to oxidative stress. Therefore, single-atom nanozymes show promising application prospects for the treatment of CNS diseases. In addition, due to the outstanding material properties and sensitivity of single-atom nanozymes, they also exhibit great advantages in detecting various CNS disease markers for diagnosis.
引用
收藏
页码:5121 / 5139
页数:18
相关论文
共 1236 条
[1]  
Benkovic S J(2003)A perspective on enzyme catalysis Science 301 1196-1202
[2]  
Hammes-Schiffer S(1991)Enzyme catalysis: Not different, just better Nature 350 121-124
[3]  
Knowles J R(1996)Artificial enzymes Chem. Rev. 96 721-758
[4]  
Murakami Y(2019)The importance of catalytic promiscuity for enzyme design and evolution Nat. Rev. Chem. 3 687-705
[5]  
Kikuchi J I(2014)Catalytically active nanomaterials: A promising candidate for artificial enzymes Acc. Chem. Res. 47 1097-1105
[6]  
Hisaeda Y(2012)Artificial enzymes based on supramolecular scaffolds Chem. Soc. Rev. 41 7890-7908
[7]  
Hayashida O(2018)Interfacing nature’s catalytic machinery with synthetic materials for semi-artificial photosynthesis Nat. Nanotechnol. 13 890-899
[8]  
Leveson-Gower R B(2020)Metal—organic-framework-engineered enzyme-mimetic catalysts Adv. Mater. 32 e2003065-28
[9]  
Mayer C(2020)Inorganic nanoparticles with enzyme-mimetic activities for biomedical applications Coord. Chem. Rev. 403 213092-24
[10]  
Roelfes G(2002)Enzyme-like catalysis by molecularly imprinted polymers Chem. Rev. 102 1-621