Ephedrine and phenylephrine induce opposite changes in cerebral and paraspinal tissue oxygen saturation, measured with near-infrared spectroscopy: a randomized controlled trial

被引:0
作者
Caroline M. Vanpeteghem
Bas Y. Bruneel
Isabeau M. Lecoutere
Stefan G. De Hert
Anneliese T. Moerman
机构
[1] University Hospital Ghent,Department of Anaesthesiology and Perioperative Medicine
来源
Journal of Clinical Monitoring and Computing | 2020年 / 34卷
关键词
Ephedrine; Near-infrared spectroscopy; Paraspinal; Phenylephrine;
D O I
暂无
中图分类号
学科分类号
摘要
While the effects of phenylephrine (PE) and ephedrine (E) on cerebral oxygen saturation (rScO2) already has been studied, the effect on paraspinal oxygen saturation (rSpsO2) is still unexplored. This study aims to assess the effect of PE and E on rScO2 and rSpsO2, measured with near-infrared spectroscopy. A randomized 4-treatment cross-over trial was designed in 28 patients under BIS-titrated anaesthesia with sevoflurane. If MAP decreased more than 20% from baseline, incremental doses of PE and/or E were given according to the randomization (group I: E–PE–E, group II: PE–E–PE, group III: E–E–E, group IV: PE–PE–PE). rScO2 and rSpsO2 on T3–T4, T9–T10 and L1–L2 were recorded. Differences in rSO2 (post-pretreatment) within each group were analyzed with paired Student’s t test. Differences in effects of PE and E on rScO2 and rSpsO2 were analyzed with linear mixed-modelling. Following PE administration, rScO2 decreased significantly (– 2.7% ± 3.5), while it remained stable following E (– 0.6% ± 3.6). Contrastingly, rSpsO2 at T3–T4, T9–T10 and L1–L2 slightly increased following PE (0.4% ± 2.5, 0.7% ± 2.0 and – 0.1% ± 1.4, respectively), while it decreased after E administration (– 1.3% ± 3.4%, – 0.7% ± 2.6% and – 1.3% ± 2.7%, respectively). Compared to E, PE administration was associated with a significant decrease in rScO2 (– 2.1%, 95% CI [– 3.1%, – 1.2%], p < 0.001). In contrast, compared to PE, E was associated with a significant decrease in rSpsO2 at T3–T4, T9–T10 and L1–L2 (– 2.0%, 95% CI [– 2.8, – 1.1], p < 0.001; – 1.4%, 95% CI [– 2.4%, – 0.4%], p = 0.006; and – 1.5%, 95% CI [– 2.3%, – 0.8%], p < 0.001, respectively). An opposite effect on rScO2 and rSpsO2 was observed after bolus administration of PE and E.
引用
收藏
页码:253 / 259
页数:6
相关论文
共 50 条
[41]   Perioperative near-infrared spectroscopy cerebral oxygen saturation in symptomatic pediatric hydrocephalus patients at risk for intracranial hypertension [J].
Lang, Shih-Shan ;
Khanna, Omaditya ;
Atkin, Natalie J. ;
Palma, Judy E. ;
Yuan, Ian ;
Storm, Phillip B. ;
Heuer, Gregory G. ;
Kennedy, Benjamin ;
Waanders, Angela J. ;
Li, Yimei ;
Huh, Jimmy W. .
JOURNAL OF NEUROSURGERY-PEDIATRICS, 2020, 25 (03) :235-241
[42]   Use of near-infrared spectroscopy to monitor regional cerebral oxygen saturation during infrarenal aortic crossclamping in piglets [J].
Ündar, A ;
LeMaire, SA ;
Schmittling, ZC ;
Coselli, JS ;
Köksoy, C ;
Deady, BA ;
Fraser, CD .
ARTIFICIAL ORGANS, 2003, 27 (09) :849-853
[43]   Initial clinical experience with near-infrared spectroscopy in assessing cerebral tissue oxygen saturation in cerebral vasospasm before and after intra-arterial verapamil injection [J].
Meng, Lingzhong ;
Settecase, Fabio ;
Xiao, Jifang ;
Yu, Zhaoxia ;
Flexman, Alana M. ;
Higashida, Randall T. .
JOURNAL OF CLINICAL NEUROSCIENCE, 2016, 26 :63-69
[44]   Influence of patient variables and sensor location on regional cerebral oxygen saturation measured by INVOS 4100 near-infrared spectrophotorneters [J].
Kishi, K ;
Kawaguchi, T ;
Yoshitani, T ;
Nagahata, T ;
Furuya, T .
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, 2003, 15 (04) :302-306
[45]   Do Cerebral Cortex Perfusion, Oxygen Delivery, and Oxygen Saturation Responses Measured by Near-Infrared Spectroscopy Differ Between Patients Who Fail or Succeed in a Spontaneous Breathing Trial? A Prospective Observational Study [J].
Zafeiris Louvaris ;
Marine Van Hollebeke ;
Diego Poddighe ;
Philippe Meersseman ;
Joost Wauters ;
Alexander Wilmer ;
Rik Gosselink ;
Daniel Langer ;
Greet Hermans .
Neurocritical Care, 2023, 38 :105-117
[46]   Do Cerebral Cortex Perfusion, Oxygen Delivery, and Oxygen Saturation Responses Measured by Near-Infrared Spectroscopy Differ Between Patients Who Fail or Succeed in a Spontaneous Breathing Trial? A Prospective Observational Study [J].
Louvaris, Zafeiris ;
Van Hollebeke, Marine ;
Poddighe, Diego ;
Meersseman, Philippe ;
Wauters, Joost ;
Wilmer, Alexander ;
Gosselink, Rik ;
Langer, Daniel ;
Hermans, Greet .
NEUROCRITICAL CARE, 2023, 38 (01) :105-117
[47]   NEAR-INFRARED SPECTROSCOPY MEASUREMENT OF SACRAL TISSUE OXYGEN SATURATION IN HEALTHY VOLUNTEERS IMMOBILIZED ON RIGID SPINE BOARDS [J].
Berg, Gina ;
Nyberg, Sue ;
Harrison, Paul ;
Baumchen, Jessica ;
Gurss, Erin ;
Hennes, Emily .
PREHOSPITAL EMERGENCY CARE, 2010, 14 (04) :419-424
[48]   A broadband multi-distance approach to measure tissue oxygen saturation with continuous wave near-infrared spectroscopy [J].
Kovacsova, Zuzana ;
Bale, Gemma ;
Veesa, Joshua Deepak ;
Dehghani, Hamid ;
Tachtsidis, Ilias .
DIFFUSE OPTICAL SPECTROSCOPY AND IMAGING VII, 2019, 11074
[49]   Evaluation of different near-infrared spectroscopy technologies for assessment of tissue oxygen saturation during a vascular occlusion test [J].
Steenhaut, Kevin ;
Lapage, Koen ;
Bove, Thierry ;
De Hert, Stefan ;
Moerman, Annelies .
JOURNAL OF CLINICAL MONITORING AND COMPUTING, 2017, 31 (06) :1151-1158
[50]   Assessment of cerebral tissue oxygen saturation in septic patients during acetazolamide provocation - A near infrared spectroscopy study [J].
Vasko, A. ;
Siro, P. ;
Laszlo, I. ;
Szatmari, Sz ;
Molnar, L. ;
Fuelesdi, B. ;
Molnar, Cs .
ACTA PHYSIOLOGICA HUNGARICA, 2014, 101 (01) :32-39