Water soluble sulconazole-β-cyclodextrin complex: physico-chemical characterization and preliminary pharmacological studies

被引：0

作者：

Liviu Miron

Mihai Mares

Valentin Nastasa

Mariana Spulber

Adrian Fifere

Mariana Pinteala

Valeria Harabagiu

Bogdan C. Simionescu

机构：

[1] Institute of Macromolecular Chemistry Petru Poni,Department of Parasitology

[2] University of Agricultural Sciences and Veterinary Medicine Ion Ionescu de la Brad, Department of Mycology

[3] University of Agricultural Sciences and Veterinary Medicine,Mycotoxicology

[4] University of Agricultural Sciences and Veterinary Medicine,Department of Pharmacology

来源：

Journal of Inclusion Phenomena and Macrocyclic Chemistry | 2009年 / 63卷

关键词：

Sulconazole nitrate; Cyclodextrin; Antifungal activity; Acute toxicity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Sulconazole-β-cyclodextrin water soluble inclusion complex was prepared by freeze drying method in distilled water. The formation of inclusion complex between β-cyclodextrin and sulconazole has been studied in a previous work. Preliminary pharmacological studies concerning the antifungal activity showed that the minimal inhibitory concentrations for 90% of the tested strains decreased. Also, the acute toxicity of the sulconazole-β-cyclodextrin complex is smaller comparing with the pure drug, analyzed alone. These results recommend the described conjugates as future promising therapeutic agents.

引用

页码：159 / 162

页数：3

共 16 条

[1]

Vanden Bossche H(1990)Mutations in cytochrome P450-dependent 14-demethylase result in decreased affinity for azole antifungals Biochem. Soc. Trans. 18 56-59

[2]

Marichal P(2006)Current status and future of antifungal therapy for systemic mycoses Recent Patents Anti-Infect. Drug Disc. 1 36-41

[3]

Gorrens J(1994)Oral azole drugs as systemic antifungal therapy N. Engl. J. Med. 330 263-272

[4]

Bellens D(2008)Inclusion complexes of Sulconazole with β-cyclodextrin and hydroxypropyl β-cyclodextrin: characterization in aqueous solution and in solid state J. Inclusion Phenom. Macrocycl. Chem. 61 41-51

[5]

Moereels H(1948)A method for obtaining and analyzing sensitivity data J Am. Stat. Assoc. 43 109-126

[6]

Janssen PAJ(2004)Past, present, and future of cyclodextrin research Pure Appl. Chem. 76 1825-1845

[7]

Nosanchuk DJ(undefined)undefined undefined undefined undefined-undefined

[8]

Como JA(undefined)undefined undefined undefined undefined-undefined

[9]

Dismukes WE(undefined)undefined undefined undefined undefined-undefined

[10]

Spulber M(undefined)undefined undefined undefined undefined-undefined

← 1 2 →