The mammalian Hippo pathway: regulation and function of YAP1 and TAZ

被引：0
作者：
Manami Kodaka
Yutaka Hata
机构：
[1] Tokyo Medical and Dental University,Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences
[2] Tokyo Medical and Dental University,Center for Brain Integration Research
来源：
Cellular and Molecular Life Sciences | 2015年 / 72卷
关键词：
Cancer; Stem cell; Cell differentiation; Development; Regeneration; Tumor suppressor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The Hippo pathway was originally identified as the signaling that controls organ size in Drosophila, with the core architecture conserved in mammals. In the mammalian Hippo pathway, mammalian Ste20-like kinases (MST1/2) and large tumor suppressor kinases (LATS1/2) regulate transcriptional co-activators, Yes-associated protein (YAP1) and Transcriptional co-activator with a PDZ-binding motif (TAZ). The Hippo pathway was initially thought to be quite straightforward; however, the identification of additional components has revealed its inherent complexity. Regulation of YAP1 and TAZ is not always dependent on MST1/2 and LATS1/2. MST1/2 and LATS1/2 play various YAP1/TAZ-independent roles, while YAP1 and TAZ cross-talk with other signaling pathways. In this review we focus on YAP1 and TAZ and discuss their regulation, function, and the consequences of their dysregulation.
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页码：285 / 306
页数：21
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