Postprandial lipemia and its relation to TCF7L2 gene polymorphisms in normoglycemic first-degree relatives of type 2 diabetes patients

We compared postprandial triglyceride (PPTg) responses to fat challenge between risk allele and wild-type variant of two common TCF7L2 gene polymorphisms to ascertain if the risk of T2DM associated with this gene is related to its effects on PPTg metabolism. Postprandial triglyceride levels were evaluated in 71 NGT subjects with at least one first-degree relative with T2DM. Restriction fragment length polymorphism was performed for genotyping of SNP rs7903146 C/T and SNP rs12255372 G/T of TCF7L2 gene, and the PPTg levels were compared in the risk allele and wild-type variant of both these SNPs. Postprandial triglyceride responses were similar in wild and risk allele groups for both the SNPs. There was no significant difference in Tg-AUC (2027.04 ± 1313.54 vs 1853.58 ± 712.00, p = 0.472) and Peak Tg levels (343.95 ± 225.08 mg/dl vs 320.60 ± 137.49 mg/dl, p = 0.591) between CC and CT + TT of SNP rs7903146. Also, no significant difference was observed between Tg-AUC (1936.41 ± 1120.77 vs 1891.38 ± 812.69, p = 0.845) and peak Tg levels (324.89 ± 186.99 mg/dl vs 330.42 ± 158.64 mg/dl, p = 0.894) between GG and GT + TT of SNP rs12255372. The present study did not find any significant difference in PPTg responses between the risk allele and wild type of rs7903146(C/T) and rs12255372 (G/T) SNPs of TCF7L2 gene.