Synthesis ofN-phenylphthalimide Derivatives as α-Glucosidase Inhibitors

被引：0
|
作者：
Wanchai Pluempanupat
Sirichai Adisakwattana
Sirintorn Yibchok-Anun
Warinthorn Chavasiri
机构：
[1] Chulalongkorn University,Natural Products Research Unit, Department of Chemistry, Faculty of Science
[2] Chulalongkorn University,Department of Pharmacology, Faculty of Veterinary Science
来源：
Archives of Pharmacal Research | 2007年 / 30卷
关键词：
-Phenylphthalimide; α-Glucosidase; Diabetes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
SixteenN-phenylphthalimide derivatives were synthesized and their ability to inhibit α-glucosidase was investigated.N-(2,4-dinitrophenyl)phthalimide was a potent inhibitor of yeast α-glucosidase (IC50; 0.158 ± 0.005 mM) and maltase (IC50; 0.051 ± 0.008 mM), whereas it did not inhibit sucrase. From a Lineweaver-Burk plot of α-glucosidase kinetics,N-(2,4-dichlorophenyl) phthalimide was found to be a competitive inhibitor of yeast α-glucosidase. These results indicate thatN-(2,4-dinitrophenyl)phthalimide could be a representative of a new group of α-glucosidase inhibitors.
引用
收藏
相关论文
共 50 条
  • [21] Advances in the natural α-glucosidase inhibitors
    Sohretoglu, Didem
    Renda, Gulin
    Arroo, Randolph
    Xiao, Jianbo
    Sari, Suat
    EFOOD, 2023, 4 (05)
  • [22] Postprandial hyperglycaemia and α-glucosidase inhibitors
    Baron, AD
    DIABETES RESEARCH AND CLINICAL PRACTICE, 1998, 40 : S51 - S55
  • [23] Synthesis, density functional theory and kinetic studies of aminopyridine based α-glucosidase inhibitors
    Rizvi, Fazila
    Ahmed, Raheel
    Bashir, Muhammad Arslan
    Ullah, Saeed
    Zafar, Humaira
    Siddiqui, Hina
    Choudhary, Muhammad Iqbal
    FUTURE MEDICINAL CHEMISTRY, 2023, 15 (19) : 1757 - 1772
  • [24] Synthesis, in vitro evaluation, and molecular docking studies of novel hydrazineylideneindolinone linked to 1,2,3-triazole derivatives as potential α-glucosidase inhibitors
    Shareghi-Boroujeni, Diba
    Iraji, Aida
    Mojtabavi, Somayeh
    Faramarzi, Mohammad Ali
    Akbarzadeh, Tahmineh
    Saeedi, Mina
    BIOORGANIC CHEMISTRY, 2021, 111
  • [25] Pyrano[2,3-b]chromone derivatives as novel dual inhibitors of α-glucosidase and α-amylase: Design, synthesis, biological evaluation, and in silico studies
    Farzaneh, Elnaz
    Mohammadi, Mohammad
    Raymand, Pooya
    Noori, Milad
    Golestani, Sahand
    Ranjbar, Sara
    Ghasemi, Younes
    Mohammadi-Khanaposhtani, Maryam
    Asadi, Mehdi
    Esfahani, Ensieh Nasli
    Rastegar, Hossein
    Larijani, Bagher
    Mahdavi, Mohammad
    Taslimi, Parham
    BIOORGANIC CHEMISTRY, 2024, 145
  • [26] Synthesis of Chalcones as Potential α-Glucosidase Inhibitors, In-Vitro and In-Silico Studies
    Mukhtar, Asma
    Shah, Shazia
    Kanwal
    Khan, Khalid Mohammed
    Khan, Shahid Ullah
    Zaib, Sumera
    Iqbal, Jamshed
    Parveen, Shahnaz
    Taha, Muhammad
    Hussain, Shafqat
    Hameed, Shahryar
    Khan, Naveed Ahmed
    Siddiqui, Ruqaiyyah
    Anwar, Ayaz
    CHEMISTRYSELECT, 2021, 6 (37): : 9933 - 9940
  • [27] Synthesis and structure-activity relationships of serotonin derivatives effect on α-glucosidase inhibition
    Takahashi, Toshiyuki
    Miyazawa, Mitsuo
    MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (08) : 1762 - 1770
  • [28] Synthesis, biological activities, and molecular docking studies of triazolo[4,3-b]triazine derivatives as a novel class of α-glucosidase and α-amylase inhibitors
    Seyfi, Soheila
    Salarinejad, Somayeh
    Moghimi, Setareh
    Toolabi, Mahsa
    Sadeghian, Nastaran
    Tuezuen, Burak
    Firoozpour, Loghman
    Ketabforoosh, Shima H. M. E.
    Taslimi, Parham
    Foroumadi, Alireza
    ARCHIV DER PHARMAZIE, 2024, 357 (07)
  • [29] Celebrex derivatives: Synthesis, α-glucosidase inhibition, crystal structures and molecular docking studies
    Kausar, Nabeela
    Ullah, Saeed
    Khan, Maria Aqeel
    Zafar, Humaira
    Atia-tul-Wahab
    Choudhary, M. Iqbal
    Yousuf, Sammer
    BIOORGANIC CHEMISTRY, 2021, 106
  • [30] Design, synthesis, and evaluation of novel substituted imidazo[1,2-c]quinazoline derivatives as potential α-glucosidase inhibitors with bioactivity and molecular docking insights
    Peytam, Fariba
    Hosseini, Faezeh Sadat
    Fathimolladehi, Reza
    Nayeri, Mohammad Javad Dehghan
    Moghadam, Mahdis Sadeghi
    Bayati, Bahareh
    Norouzbahari, Maryam
    Foroumadi, Roham
    Bonyasi, Fahimeh
    Divsalar, Ruzbehan
    Mojtabavi, Somayeh
    Faramarzi, Mohammad Ali
    Tehrani, Maliheh Barazandeh
    Firoozpour, Loghman
    Foroumadi, Alireza
    SCIENTIFIC REPORTS, 2024, 14 (01):
12345