DNA-damage response and repair activities at uncapped telomeres depend on RNF8

被引：0
|
作者：
Marieke H. Peuscher
Jacqueline J. L. Jacobs
机构：
[1] The Netherlands Cancer Institute,Division of Molecular Genetics
来源：
Nature Cell Biology | 2011年 / 13卷
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摘要：
The E3 ligase RNF8 is recruited to double-strand breaks in DNA to promote repair. Jacobs and colleagues discovered that RNF8 also goes to unprotected telomeres, where it mediates non-homologous end-joining of chromosome ends and contributes to telomere-induced genomic instability.
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页码：1139 / 1145
页数：6
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