Analysis of SARS-CoV-2 vertical transmission during pregnancy

被引:0
作者
Claudio Fenizia
Mara Biasin
Irene Cetin
Patrizia Vergani
Davide Mileto
Arsenio Spinillo
Maria Rita Gismondo
Francesca Perotti
Clelia Callegari
Alessandro Mancon
Selene Cammarata
Ilaria Beretta
Manuela Nebuloni
Daria Trabattoni
Mario Clerici
Valeria Savasi
机构
[1] University of Milan,Department of Pathophysiology and Transplantation
[2] University of Milan,Department of Biomedical and Clinical Sciences
[3] Department of Woman,Department of Maternal Fetal Medicine
[4] Mother and Neonate Buzzi Children’s Hospital,Department of Obstetrics and Gynecology
[5] ASST Fatebenefratelli‐Sacco,Division of Infectious Diseases
[6] Department of Biomedical and Clinical Sciences,undefined
[7] Fondazione MBBM,undefined
[8] San Gerardo Hospital,undefined
[9] University of Milan-Bicocca,undefined
[10] Clinical Microbiology,undefined
[11] Virology and Bio-emergence Diagnosis,undefined
[12] ASST Fatebenefratelli-Sacco,undefined
[13] Department of Biomedical and Clinical Sciences,undefined
[14] University of Milan,undefined
[15] Department of Obstetrics and Gynecology,undefined
[16] IRCCS Fondazione Policlinico San Matteo,undefined
[17] University of Pavia,undefined
[18] IRCCS Fondazione Policlinico San Matteo,undefined
[19] Unit of Obstetrics and Gynecology,undefined
[20] ASST Fatebenefratelli-Sacco,undefined
[21] Department of Biological and Clinical Sciences,undefined
[22] University of Milan,undefined
[23] San Gerardo Hospital,undefined
[24] ASST Monza,undefined
[25] Pathology Unit,undefined
[26] ASST Fatebenfretalli-Sacco,undefined
[27] Department of Biological and Clinical Sciences,undefined
[28] University of Milan,undefined
[29] IRCCS Fondazione don Carlo Gnocchi,undefined
来源
Nature Communications | / 11卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
The impact of SARS-CoV-2 infection during gestation remains unclear. Here, we analyse the viral genome on maternal and newborns nasopharyngeal swabs, vaginal swabs, maternal and umbilical cord plasma, placenta and umbilical cord biopsies, amniotic fluids and milk from 31 mothers with SARS-CoV-2 infection. In addition, we also test specific anti-SARS-CoV-2 antibodies and expression of genes involved in inflammatory responses in placentas, and in maternal and umbilical cord plasma. We detect SARS-CoV-2 genome in one umbilical cord blood and in two at-term placentas, in one vaginal mucosa and in one milk specimen. Furthermore, we report the presence of specific anti-SARS-CoV-2 IgM and IgG antibodies in one umbilical cord blood and in one milk specimen. Finally, in the three documented cases of vertical transmission, SARS-CoV-2 infection was accompanied by a strong inflammatory response. Together, these data support the hypothesis that in utero SARS-CoV-2 vertical transmission, while low, is possible. These results might help defining proper obstetric management of COVID-19 pregnant women, or putative indications for mode and timing of delivery.
引用
收藏
相关论文
共 61 条
[1]  
Huang C(2020)Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet 395 497-506
[2]  
Grasselli G(2020)Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy JAMA 323 1574-1581
[3]  
Dong E(2020)An interactive web-based dashboard to track COVID-19 in real time Lancet Infect. Dis. 20 533-534
[4]  
Du H(2004)Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome Am. J. Obstet. Gynecol. 191 292-297
[5]  
Gardner L(2019)Middle East respiratory syndrome coronavirus (MERS-CoV) infection during pregnancy: report of two cases & review of the literature J. Microbiol. Immunol. Infect. 52 501-503
[6]  
Wong SF(2020)Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Lancet 395 809-815
[7]  
Alfaraj SH(2020)Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia Transl. Pediatr. 9 51-60–60
[8]  
Al-Tawfiq JA(2020)A case of 2019 novel coronavirus in a pregnant woman with preterm delivery Clin. Infect. Dis. 55 E009-E009
[9]  
Memish ZA(2020)Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province Chin. J. Obstet. Gynecol. 13 818-820
[10]  
Chen H(2020)Unlikely SARS-CoV-2 vertical transmission from mother to child: A case report J. Infect. Public Health 15 e0230295-E650