Vitamin D in individuals before onset of rheumatoid arthritis - relation to vitamin D binding protein and its associated genetic variants

被引：13

作者：

Brink M. ^{[1
]}

Johansson L. ^{[1
]}

Nygren E. ^{[1
]}

Arlestig L. ^{[1
]}

Hultdin J. ^{[2
]}

Rantapää-Dahlqvist S. ^{[1
]}

机构：

[1] Umeå University, Department of Public Health and Clinical Medicine/ Rheumatology, Umeå

[2] Clinical Chemistry, Umeå University, Department of Medical Biosciences, Umeå

来源：

BMC Rheumatology | / 2卷 / 1期

关键词：

Case-control study; Pre-symptomatic individuals; Rheumatoid arthritis; Vitamin D; Vitamin D binding protein;

D O I：

10.1186/s41927-018-0033-8

中图分类号：

学科分类号：

摘要：

Background: Vitamin D has been implicated as being involved in the aetio-pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA). Previous studies present contradictory results. Vitamin D binding protein (DBP), the major transport protein, is also involved in various inflammatory processes. The aim of this study was to investigate the relationship between circulating levels of 25-hydroxyvitamin D [25(OH) D], DBP and polymorphisms in group-specific component (GC) in pre-symptomatic individuals and matched controls within prospective cohorts of the Northern Sweden. Methods: Blood samples donated to the Medical Biobank prior to the onset of symptoms of RA (n = 515, mean [SD] time before the onset of symptoms 6.2 [9.3] years) and from matched (2:1) population-based controls (n = 267) were used. Plasma 25(OH) vitamin D levels were analyzed using liquid chromatography tandem-mass spectrometry and DBP levels were analyzed using enzyme-linked immunosorbent assay. GC polymorphisms (rs4588 and rs7041) were analyzed with TaqMan assays (Applied Biosystems). Results: Levels of 25(OH) D or DBP were not statistically different between pre-symptomatic individuals and controls in a crude, or a multiple-adjusted logistic regression model. However, an increased risk for future RA was found in females of DBP (OR 1.014 [95%CI 1.001-1.028]) per 10 mg/L adjusted for carriage of the minor allele of rs4588, in a multiple-adjusted model (p < 0.05). Conclusions: This study indicated that vitamin D is not associated with the future risk of RA although increasing levels of DBP were however, associated with an increased risk of disease in females carrying the minor allele of a DBP encoding SNP. © 2018 The Author(s).

引用

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