The p53 transcriptional synapse: activation on demand

被引：0
|
作者：
Genrich V Tolstonog
Wolfgang Deppert
机构：
[1] Genrich V. Tolstonog and Wolfgang Deppert are at the Heinrich-Pette-Institute for Experimental Virology and Immunology,
[2] Martinistr. 52,undefined
[3] D-20251 Hamburg,undefined
[4] Germany.,undefined
来源：
Nature Structural & Molecular Biology | 2009年 / 16卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The adequate and on-time response of cellular transcription to internal needs and external stimuli is a delicate task. Is the transcriptional regulator p53 on call to permit rapid activation of its target genes? A new study reports interplay of p53 with a previously unidentified regulator, calcineurin-binding protein 1 (Cabin1), and provides evidence for such a mechanism.
引用
收藏
页码：900 / 901
页数：1
相关论文
共 50 条
  • [1] The p53 transcriptional synapse: activation on demand
    Tolstonog, Genrich V.
    Deppert, Wolfgang
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (09): : 900 - 901
  • [2] The transcriptional program following p53 activation
    Zhao, R
    Gish, K
    Murphy, M
    Yin, Y
    Notterman, D
    Hoffman, WH
    Tom, E
    Mack, DH
    Levine, AJ
    COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2000, 65 : 475 - 482
  • [3] Dynamics and Molecular Mechanisms of p53 Transcriptional Activation
    Offutt, Tavina L.
    Ieong, Pek U.
    Demir, Ozlem
    Amaro, Rommie E.
    BIOCHEMISTRY, 2018, 57 (46) : 6528 - 6537
  • [4] p53 Transcriptional activation domain - A molecular chameleon?
    Kaustov, Lilia
    Yi, Gwan-Su
    Ayed, a Ayed
    Bochkareva, Elena
    Bochkarev, Alexey
    Arrowsmith, Cheryl H.
    CELL CYCLE, 2006, 5 (05) : 489 - 494
  • [5] Transcriptional activation of p53 by Pitx1
    Liu, D. X.
    Lobie, P. E.
    CELL DEATH AND DIFFERENTIATION, 2007, 14 (11): : 1893 - 1907
  • [6] Transcriptional activation of p53 by Pitx1
    D X Liu
    P E Lobie
    Cell Death & Differentiation, 2007, 14 : 1893 - 1907
  • [7] In vitro transcriptional activation of p21 promoter by p53
    Kim, TK
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 234 (02) : 300 - 302
  • [8] Transcriptional activation of the human glutathione peroxidase promoter by p53
    Tan, MJ
    Li, SJ
    Swaroop, MJ
    Guan, KL
    Oberley, LW
    Sun, Y
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (17) : 12061 - 12066
  • [9] TRANSCRIPTIONAL ACTIVATION BY P53 CORRELATES WITH SUPPRESSION OF GROWTH BUT NOT TRANSFORMATION
    CROOK, T
    MARSTON, NJ
    SARA, EA
    VOUSDEN, KH
    CELL, 1994, 79 (05) : 817 - 827
  • [10] Seeking Synergy in p53 Transcriptional Activation for Cancer Therapy
    Cheok, Chit Fang
    Lane, David P.
    DISCOVERY MEDICINE, 2012, 14 (77) : 263 - 271
12345