Synthesis and anti-acetylcholinesterase activity of benzotriazinone-triazole systems

被引：0
作者：
SETAREH MOGHIMI
FERESHTEH GOLI-GARMROODI
HEDIEH PILALI
MOHAMMAD MAHDAVI
LOGHMAN FIROOZPOUR
HAMID NADRI
ALIREZA MORADI
ALI ASADIPOUR
ABBAS SHAFIEE
ALIREZA FOROUMADI
机构：
[1] Tehran University of Medical Sciences,Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center
[2] Tehran University of Medical Sciences,Drug Design and Development Research Center
[3] Shahid Sadoughi University of Medical Sciences,Department of Medicinal Chemistry, Faculty of Pharmacy
[4] Kerman University of Medical Sciences,Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Institute of Neuropharmacology
来源：
Journal of Chemical Sciences | 2016年 / 128卷
关键词：
triazole; benzotriazinone; diazonium chemistry; nanocatalyst; acetylcholinesterase;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An approach for the construction of benzotriazinone-triazole system is described. The synthesis is based on diazonium chemistry and subsequent intramolecular heteroatom-heteroatom bond formation. The introduction of triazole moiety occurred via click reaction catalyzed by nano-sized copper, supported on modified silica mesopore KIT-5 leading to the desired products in excellent yield. Also, in vitro acetylcholinesterase (AChE) inhibitory activities of the target compounds were screened by Ellman’s method.
引用
收藏
页码：1445 / 1449
页数：4
相关论文
共 50 条
[31]   ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTI-ACETYLCHOLINESTERASE ACTIVITIES OF ELEVEN EXTRACTS OF MOROCCAN PLANTS [J].
Miguel, Maria ;
Bouchmaa, Najat ;
Aazza, Smail ;
Gaamoussi, Farah ;
Lyoussi, Badiaa .
FRESENIUS ENVIRONMENTAL BULLETIN, 2014, 23 (06) :1375-1388
[32]   Lawsonia inermis flower aqueous extract expressed better anti-alpha-glucosidase and anti-acetylcholinesterase activity and their molecular dynamics [J].
Shahanaj, Ismail ;
Ramakrishnan, Jaganathan ;
Poomani, Kumaradhas ;
Devarajan, Natarajan .
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023, 41 (23) :13752-13765
[33]   Anti-acetylcholinesterase mechanism of kaempferol and its synergistic effect with galanthamine hydrobromide [J].
Shi, Wenli ;
Zhang, Guowen ;
Liao, Yijing ;
Fei, Xiaoyun ;
Gong, Deming ;
Hu, Xing .
FOOD BIOSCIENCE, 2023, 56
[34]   Anti-Acetylcholinesterase and Antioxidant Appraisal of the Bulb Extracts of Five Sternbergia Species [J].
Orhan, Ilkay Erdogan ;
Yilmaz, Betul Sever ;
Altun, M. Levent ;
Saltan, Gulcin ;
Sener, Bilge .
RECORDS OF NATURAL PRODUCTS, 2011, 5 (03) :193-201
[35]   Phenolic composition, antioxidant and anti-acetylcholinesterase activities of the Tunisian Scabiosa arenaria [J].
Hlila, Malek Besbes ;
Omri, Amel ;
Ben Jannet, Hichem ;
Lamari, Ali ;
Aouni, Mahjoub ;
Selmi, Boulbaba .
PHARMACEUTICAL BIOLOGY, 2013, 51 (05) :525-532
[36]   Screening of Spice Extracts Possessing Anti-Acetylcholinesterase Activity and Active Principle of Bitter Ginger, Rhizome of Zingiber zerumbet [J].
Murata, Kazuya ;
Ishida, Yusuke ;
Nishio, Arisa ;
Nakagawa, Sayaka ;
Kawamoto, Hirokazu ;
Matsuda, Hideaki .
NATURAL PRODUCT COMMUNICATIONS, 2017, 12 (07) :1053-1056
[37]   Antioxidant capacity, anti-acetylcholinesterase activity and inhibitory effect on lipid peroxidation in mice brain homogenate of Achillea millefolium [J].
Barut, Elif Nur ;
Barut, Burak ;
Engin, Seckin ;
Yildirim, Sercan ;
Yasar, Ahmet ;
Turkis, Sevda ;
Ozel, Arzu ;
Sezen, Feride Sena .
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, 2017, 42 (04) :493-502
[38]   Anti-acetylcholinesterase and Antioxidant Activity of Essential Oils from Hedychium gardnerianum Sheppard ex Ker-Gawl [J].
Arruda, Miguel ;
Viana, Hugo ;
Rainha, Nuno ;
Neng, Nuno R. ;
Rosa, Jose Silvino ;
Nogueira, Jose M. F. ;
Barreto, Maria do Carmo .
MOLECULES, 2012, 17 (03) :3082-3092
[39]   Investigation of Experimental and In Silico Physicochemical Properties of Thiazole-Pyridinium Anti-Acetylcholinesterase Derivatives with Potential Anti-Alzheimer's Activity [J].
Ghotbi, Golaleh ;
Hamzeh-Mivehroud, Maryam ;
Taghvimi, Arezou ;
Davaran, Soodabeh ;
Dastmalchi, Siavoush .
PHARMACEUTICAL SCIENCES, 2021, 27 (03) :366-377
[40]   Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease [J].
Lin, H. Q. ;
Ho, Michelle T. ;
Lau, Lesley S. ;
Wong, Kelvin K. ;
Shaw, P. C. ;
Wan, David C. C. .
CHEMICO-BIOLOGICAL INTERACTIONS, 2008, 175 (1-3) :352-354
12345