Synthesis and anti-acetylcholinesterase activity of benzotriazinone-triazole systems

被引：0
作者：
SETAREH MOGHIMI
FERESHTEH GOLI-GARMROODI
HEDIEH PILALI
MOHAMMAD MAHDAVI
LOGHMAN FIROOZPOUR
HAMID NADRI
ALIREZA MORADI
ALI ASADIPOUR
ABBAS SHAFIEE
ALIREZA FOROUMADI
机构：
[1] Tehran University of Medical Sciences,Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center
[2] Tehran University of Medical Sciences,Drug Design and Development Research Center
[3] Shahid Sadoughi University of Medical Sciences,Department of Medicinal Chemistry, Faculty of Pharmacy
[4] Kerman University of Medical Sciences,Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Institute of Neuropharmacology
来源：
Journal of Chemical Sciences | 2016年 / 128卷
关键词：
triazole; benzotriazinone; diazonium chemistry; nanocatalyst; acetylcholinesterase;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An approach for the construction of benzotriazinone-triazole system is described. The synthesis is based on diazonium chemistry and subsequent intramolecular heteroatom-heteroatom bond formation. The introduction of triazole moiety occurred via click reaction catalyzed by nano-sized copper, supported on modified silica mesopore KIT-5 leading to the desired products in excellent yield. Also, in vitro acetylcholinesterase (AChE) inhibitory activities of the target compounds were screened by Ellman’s method.
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页码：1445 / 1449
页数：4
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