Synthesis and anti-acetylcholinesterase activity of benzotriazinone-triazole systems

被引：0

作者：

SETAREH MOGHIMI

FERESHTEH GOLI-GARMROODI

HEDIEH PILALI

MOHAMMAD MAHDAVI

LOGHMAN FIROOZPOUR

HAMID NADRI

ALIREZA MORADI

ALI ASADIPOUR

ABBAS SHAFIEE

ALIREZA FOROUMADI

机构：

[1] Tehran University of Medical Sciences,Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center

[2] Tehran University of Medical Sciences,Drug Design and Development Research Center

[3] Shahid Sadoughi University of Medical Sciences,Department of Medicinal Chemistry, Faculty of Pharmacy

[4] Kerman University of Medical Sciences,Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Institute of Neuropharmacology

来源：

Journal of Chemical Sciences | 2016年 / 128卷

关键词：

triazole; benzotriazinone; diazonium chemistry; nanocatalyst; acetylcholinesterase;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An approach for the construction of benzotriazinone-triazole system is described. The synthesis is based on diazonium chemistry and subsequent intramolecular heteroatom-heteroatom bond formation. The introduction of triazole moiety occurred via click reaction catalyzed by nano-sized copper, supported on modified silica mesopore KIT-5 leading to the desired products in excellent yield. Also, in vitro acetylcholinesterase (AChE) inhibitory activities of the target compounds were screened by Ellman’s method.

引用

页码：1445 / 1449

页数：4

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