History and Present State of Targeted Intrathecal Drug Delivery

被引：0
作者：
Syed Rizvi
Krishna Kumar
机构：
[1] University of Saskatchewan,Division of Neurology, Department of Medicine, Royal University Hospital
[2] University of Saskatchewan,Section of Neurosurgery, Department of Surgery, Regina General Hospital
来源：
Current Pain and Headache Reports | 2015年 / 19卷
关键词：
Neuromodulation; Intrathecal drug delivery; Chronic pain; Failed back surgery syndrome; Complex regional pain syndrome; Neuropathic pain;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Nearly 50 years ago, the seminal experiments of Melzack and Wall, culminating in the gate control theory, coupled with the discovery of endogenous opioid receptors, helped shape modern understandings of pain and provided interventionalists a potent therapeutic gateway to neuraxial analgesia. This paper emphasizes the historical antecedents, present state, and emerging future of the neuromodulatory technique of targeted intrathecal drug delivery (TIDD) for chronic pain. The strengths of TIDD are its customizability, reversibility, programmability, and low risk profile. Its benefits are evidenced by improved pain relief and quality of life and reduced demand for health-care resources.
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