Free Immunoglobulin Light Chains as Criteria of Extracorporeal Hemocorrection in Patients with Monoclonal Gammopathies

被引：0
作者：
N. V. Lyubimova
Yu. S. Timofeeva
E. G. Gromova
L. S. Kuznetsova
O. M. Votyakova
N. E. Kushlinskii
机构：
[1] Ministry of Health of the Russian Federation,N. N. Blokhin Russian Cancer Research Center
来源：
Bulletin of Experimental Biology and Medicine | 2017年 / 163卷
关键词：
immunoglobulins free light chains; monoclonal gammopathy; multiple myeloma; lymphoma; extracorporeal hemocorrection;
D O I：
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学科分类号：
摘要：
Elimination of free immunoglobulin light chains with the use of EMic2 selective filters was carried out in 12 patients with monoclonal gammopathies and high production of free immunoglobulin light chains. We showed that extracorporeal detoxification for direct removal of excessive free immunoglobulin light chains from the circulation is advisable for these patients, irrespective of the presence and severity of renal insufficiency. Rapid reduction or elimination of free light chains of immunoglobulins in the course of selective extracorporeal elimination helps to prevent the development of irreversible renal failure and to perform adequate antitumor therapy.
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页码：493 / 496
页数：3
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