Epilepsy with Basal Ganglia Calcification and Hypocalcemia: a Case Report

Basal ganglia calcification (BGC) can be seen up to 20% of the general population, with most cases being asymptomatic. Some have been reported to be associated with diseases of the endocrine system or neurological disorders. The underlying causes of calcium deposition in these conditions are not well understood. This case report describes a 26-year-old woman with a history of epilepsy and BGC in the brain. She also exhibited systemic features of short stature, round face, obesity and brachydactyly. Blood tests revealed hypocalcemia, hyperphosphatemia, and elevated parathyroid hormone levels. In her case, BCG-associated epilepsy along with systemic manifestations lead to the diagnosis of pseudohypoparathyroidism. She was then prescribed vitamin D and calcium supplements, resulting in improvement in her calcium and phosphate levels. This case highlights the rare association of BGC with epilepsy. Several notable features observed in both current and previously reported cases can be crucial indicators to aid treating physicians in identifying certain pathological conditions related to endocrinopathies.