Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility

被引：0
作者：
Mamoona Noreen
Muhammad Arshad
机构：
[1] National University of Sciences and Technology (NUST),Atta
[2] University of Sargodha,ur
来源：
Immunologic Research | 2015年 / 62卷
关键词：
Polymorphism; Disease; Susceptibility; Toll like receptors; Mal/TIRAP;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Toll like receptors (TLRs) play a crucial role in regulation of innate as well as adaptive immunity. TLRs recognize a distinct but limited repertoire of conserved microbial products. Ligand binding to TLRs activates the signaling cascade and results in activation of multiple inflammatory genes. Variation in this immune response is under genetic control. Polymorphisms in genes associated with inflammatory pathway especially influence the outcome of diseases. TLR2 makes heterodimer with TLR1 or TLR6 and recognizes a wide variety of microbial ligands. In this review, we summarize studies of polymorphisms in genes encoding TLR1, TLR2, TLR4, TLR6, and most polymorphic adaptor protein, Mal/TIRAP, revealing their effect on susceptibility to diseases.
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页码：234 / 252
页数：18
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