Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility

被引：0
作者：
Mamoona Noreen
Muhammad Arshad
机构：
[1] National University of Sciences and Technology (NUST),Atta
[2] University of Sargodha,ur
来源：
Immunologic Research | 2015年 / 62卷
关键词：
Polymorphism; Disease; Susceptibility; Toll like receptors; Mal/TIRAP;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Toll like receptors (TLRs) play a crucial role in regulation of innate as well as adaptive immunity. TLRs recognize a distinct but limited repertoire of conserved microbial products. Ligand binding to TLRs activates the signaling cascade and results in activation of multiple inflammatory genes. Variation in this immune response is under genetic control. Polymorphisms in genes associated with inflammatory pathway especially influence the outcome of diseases. TLR2 makes heterodimer with TLR1 or TLR6 and recognizes a wide variety of microbial ligands. In this review, we summarize studies of polymorphisms in genes encoding TLR1, TLR2, TLR4, TLR6, and most polymorphic adaptor protein, Mal/TIRAP, revealing their effect on susceptibility to diseases.
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页码：234 / 252
页数：18
相关论文
共 1245 条
[1]  
Beutler B(2004)Innate immunity: an overview Mol Immunol 40 845-859
[2]  
Barber RC(2006)Innate immunity SNPs are associated with risk for severe sepsis after burn injury Clin Med Res 4 250-255
[3]  
Chang LY(1996)The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults Cell 86 973-983
[4]  
Arnoldo BD(2012)Pillars article: the dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996. 86: 973–983 J Immunol 188 5210-5220
[5]  
Purdue GF(2004)The road to Toll Nat Rev Immunol 4 521-527
[6]  
Hunt JL(1997)A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature 388 394-397
[7]  
Horton JW(2012)Accessory molecules for Toll-like receptors and their function Nat Rev Immunol 12 168-179
[8]  
Lemaitre B(2006)New insights into the regulation of TLR signaling J Leukoc Biol 80 220-226
[9]  
Nicolas E(2010)Regulation of adaptive immunity by the innate immune system Science 327 291-295
[10]  
Michaut L(2003)Role of adapters in Toll-like receptor signalling Biochem Soc Trans 31 637-642
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