The polymorphisms of bovine PCSK1 gene and their associations with growth traits

被引：0
作者：
Limin Shan
Jiajie Sun
Chunlei Zhang
Xingtang Fang
Chuzhao Lei
Xianyong Lan
Hong Chen
机构：
[1] Xuzhou Normal University,Institute of Cellular and Molecular Biology
[2] Northwest A&F University,College of Animal Science and Technology
[3] Shaanxi Key Laboratory of Molecular Biology for Agriculture,undefined
来源：
Genes & Genomics | 2011年 / 33卷
关键词：
Cattle; Growth traits; Mutation; gene; SSCP;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Proprotein convertase 1 (PCSK1) is an endopeptidase involved in proteolytic processing of peptide hormone precursors in granules of the regulated secretory pathway of endocrine cells and mutations in PCSK1 gene are thought to cause obesity. In the present study, based on PCR-SSCP and DNA sequencing methods, polymorphisms of the PCSK1 gene were detected in 858 individuals from five breeds (Nanyang cattle, Qinchuan cattle, Jiaxian cattle, Luxi cattle and Chinese Holstein). The results showed that only P8 locus showed polymorphisms and 3 synonymous SNPs of PCSK1 gene were identified. Additionally, significant statistical difference was found in bovine birth weight and diplotype MM were 7.35% higher than diplotype XY.
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页码：57 / 63
页数：6
相关论文
共 182 条
[1]  
Barrett J.C.(2005)Haploview: Analysis and visualization of LD and haplotype maps Bioinformatics 21 263-265
[2]  
Fry B.(1993)Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2 Biochem. J. 294 735-743
[3]  
Maller J.(2004)NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol J. Biol. Chem. 279 48865-48875
[4]  
Daly M.J.(2008)Common nonsynonymous variants in PCSK1 confer risk of obesity Nat. Genet. 40 943-945
[5]  
Benjannet S.(1980)Construction of a genetic linkage map in man using restriction fragment length polymorphisms Am. J. Hum. Genet. 32 314-331
[6]  
Rondeau N.(2004)A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups Hum. Mol. Genet. 13 2361-2368
[7]  
Paquet L.(2002)Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity J. Boil. Chem. 277 11265-11275
[8]  
Boudreault A.(2007)Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3 J. Clin. Endocrinol. Metab. 92 3369-3373
[9]  
Lazure C.(1994)Gene organization of the mouse pro-hormone and pro-protein convertase PC1 DNA Cell Biol. 13 395-407
[10]  
Chrétien M.(2009)Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine Regul. Pept. 152 54-60
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