Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men

被引：0
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作者：
Lars Fugger
Arne Svejgaard
机构：
[1] Aarhus University Hospital,
[2] Skejby Sygehus,undefined
[3] Rigshospitalet,undefined
[4] Copenhagen University Hospital,undefined
来源：
Arthritis Research & Therapy | / 2卷
关键词：
human leukocyte antigen; rheumatoid arthritis; transgenic mice;
D O I：
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学科分类号：
摘要：
Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed.
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