Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk

被引：0
作者：
Michael S. Shawky
Carmela Ricciardelli
Megan Lord
John Whitelock
Vito Ferro
Kara Britt
Erik W. Thompson
机构：
[1] University of Alexandria,Department of Head and Neck and Endocrine Surgery, Faculty of Medicine
[2] Waikato Hospital,Department of Surgery
[3] University of Adelaide,School of Medicine, Robinson Research Institute
[4] University of New South Wales,Graduate School of Biomedical Engineering
[5] University of Queensland,School of Chemistry and Molecular Biosciences
[6] Peter MacCallum Cancer Centre,The Sir Peter MacCallum Department of Oncology
[7] University of Melbourne,Institute of Health and Biomedical Innovation and School of Biomedical Science
[8] Queensland University of Technology,Department of Surgery, St Vincent’s Hospital
[9] University of Melbourne,undefined
来源：
Journal of Mammary Gland Biology and Neoplasia | 2015年 / 20卷
关键词：
Breast cancer; Mammographic density; Proteoglycans; Extracellular matrix; Syndecan; Versican; Perlecan; Glypican; Heparanase;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Although increased mammographic density (MD) has been well established as a marker for increased breast cancer (BC) risk, its pathobiology is far from understood. Altered proteoglycan (PG) composition may underpin the physical properties of MD, and may contribute to the associated increase in BC risk. Numerous studies have investigated PGs, which are a major stromal matrix component, in relation to MD and BC and reported results that are sometimes discordant. Our review summarises these results and highlights discrepancies between PG associations with BC and MD, thus serving as a guide for identifying PGs that warrant further research towards developing chemo-preventive or therapeutic agents targeting pre-invasive or invasive breast lesions, respectively.
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页码：121 / 131
页数：10
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