Nuclear hormone receptors in podocytes

被引：0
作者：
Simran Khurana
Leslie A Bruggeman
Hung-Ying Kao
机构：
[1] Case Western Reserve University (CWRU) and the Comprehensive Cancer Center of CWRU,Department of Biochemistry, School of Medicine
[2] Case Western Reserve University School of Medicine,Rammelkamp Center for Education and Research and Department of Medicine, MetroHealth Medical Center
来源：
Cell & Bioscience | / 2卷
关键词：
Glucocorticoid receptor; Mineralocorticoid receptor; Podocyte injury; Proteinuria; Focal segmental glomerulosclerosis (FSGS); Diabetic and non-diabetic nephropathy;
D O I：
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学科分类号：
摘要：
Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome. However, their role in kidney diseases is still evolving, despite their ligands being used clinically to treat renal diseases for decades. This review will discuss the progress of our understanding of the role of nuclear receptors and their ligands in kidney physiology with emphasis on their roles in treating glomerular disorders and podocyte injury repair responses.
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