Nuclear hormone receptors in podocytes

被引：0
作者：
Simran Khurana
Leslie A Bruggeman
Hung-Ying Kao
机构：
[1] Case Western Reserve University (CWRU) and the Comprehensive Cancer Center of CWRU,Department of Biochemistry, School of Medicine
[2] Case Western Reserve University School of Medicine,Rammelkamp Center for Education and Research and Department of Medicine, MetroHealth Medical Center
来源：
Cell & Bioscience | / 2卷
关键词：
Glucocorticoid receptor; Mineralocorticoid receptor; Podocyte injury; Proteinuria; Focal segmental glomerulosclerosis (FSGS); Diabetic and non-diabetic nephropathy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome. However, their role in kidney diseases is still evolving, despite their ligands being used clinically to treat renal diseases for decades. This review will discuss the progress of our understanding of the role of nuclear receptors and their ligands in kidney physiology with emphasis on their roles in treating glomerular disorders and podocyte injury repair responses.
引用
收藏
相关论文
共 815 条
  • [1] Mangelsdorf DJ(1995)The nuclear receptor superfamily: the second decade Cell 83 835-839
  • [2] Thummel C(2003)Nuclear receptors and the control of metabolism Annu Rev Physiol 65 261-311
  • [3] Beato M(2006)Overview of nomenclature of nuclear receptors Pharmacol Rev 58 685-704
  • [4] Herrlich P(1995)Nuclear receptors. Dymer, dymer binding tight Nature 375 359-360
  • [5] Schutz G(1994)The steroid/nuclear receptors: from three-dimensional structure to complex function Vitam Horm 49 1-47
  • [6] Umesono K(1996)Transcriptional control: how nuclear receptors get turned on Curr Biol 6 372-374
  • [7] Blumberg B(2004)Nuclear receptors: the evolution of diversity Sci STKE 2004 pe4-1909
  • [8] Kastner P(2003)Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation Mol Endocrinol 17 1901-2925
  • [9] Mark M(1998)Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes Proc Natl Acad Sci U S A 95 2920-852
  • [10] Chambon P(2000)Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription Cell 103 843-713
12345678910