Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection

被引:0
作者
Tao Zuo
Sunny H. Wong
Chun Pan Cheung
Kelvin Lam
Rashid Lui
Kitty Cheung
Fen Zhang
Whitney Tang
Jessica Y. L. Ching
Justin C. Y. Wu
Paul K. S. Chan
Joseph J. Y. Sung
Jun Yu
Francis K. L. Chan
Siew C. Ng
机构
[1] The Chinese University of Hong Kong,Department of Medicine and Therapeutics
[2] The Chinese University of Hong Kong,Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, LKS Institute of Health Science
[3] The Chinese University of Hong Kong,Center for Gut Microbiota Research
[4] The Chinese University of Hong Kong,Shenzhen Research Institute
[5] The Chinese University of Hong Kong,Department of Microbiology
来源
Nature Communications | / 9卷
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摘要
Fecal microbiota transplantation (FMT) is effective in treating recurrent Clostridium difficile infection (CDI). Bacterial colonization in recipients after FMT has been studied, but little is known about the role of the gut fungal community, or mycobiota. Here, we show evidence of gut fungal dysbiosis in CDI, and that donor-derived fungal colonization in recipients is associated with FMT response. CDI is accompanied by over-representation of Candida albicans and decreased fungal diversity, richness, and evenness. Cure after FMT is associated with increased colonization of donor-derived fungal taxa in recipients. Recipients of successful FMT (“responders”) display, after FMT, a high relative abundance of Saccharomyces and Aspergillus, whereas “nonresponders” and individuals treated with antibiotics display a dominant presence of Candida. High abundance of C. albicans in donor stool also correlates with reduced FMT efficacy. Furthermore, C. albicans reduces FMT efficacy in a mouse model of CDI, while antifungal treatment reestablishes its efficacy, supporting a potential causal relationship between gut fungal dysbiosis and FMT outcome.
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