Personality Mediation of Genetic Effects on Attention-Deficit/Hyperactivity Disorder

被引：0
作者：
Michelle M. Martel
Molly Nikolas
Katherine Jernigan
Karen Friderici
Joel T. Nigg
机构：
[1] University of New Orleans,Psychology Department
[2] Michigan State University,Psychology Department
[3] Michigan State University,Microbiology and Molecular Genetics
[4] Oregon Health and Sciences University,Psychiatry Department
来源：
Journal of Abnormal Child Psychology | 2010年 / 38卷
关键词：
ADHD; Genetics; Personality; Disruptive behaviors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Personality traits may be viable candidates for mediators of the relationship between genetic risk and ADHD. Participants were 578 children (331 boys; 320 children with ADHD) between the ages of six and 18. Parents and teachers completed a comprehensive, multi-stage diagnostic procedure to assess ADHD and comorbid disorders. Mother completed the California Q-Sort to assess child Big Five personality traits. Children provided buccal samples of DNA which were assayed for selected markers on DRD4, DAT1, and ADRA2A. An additive genetic risk composite was associated with ADHD symptoms and maladaptive personality traits; maladaptive personality traits were associated with ADHD symptoms. Low conscientiousness and high neuroticism partially mediated the relationship between genetic risk and ADHD symptoms. Mediation effects for conscientiousness were specific to inattentive symptoms; effects for neuroticism generalized to all disruptive behaviors. High neuroticism and low conscientiousness may be useful as early markers for children at risk for ADHD.
引用
收藏
页码：633 / 643
页数：10
相关论文
共 217 条
  • [1] Arnold LE(1997)National institute of mental health collaborative multimodal treatment study of children with ADHD (the MTA). Design challenges and choices Archives of General Psychiatry 54 865-870
  • [2] Abikoff HB(2001)DRD4 related to infant attention and information processing: a developmental link to ADHD? Psychiatric Genetics 11 31-35
  • [3] Cantwell DP(2005)Functional neuroimaging of Attention-Deficit/Hyperactivity Disorder: a review and suggested future directions Biological Psychiatry 57 1273-1284
  • [4] Conners CK(1992)A “common-language” version of the California Child Q-Set for personality assessment Psychological Assessment 4 512-523
  • [5] Elliott G(2000)Heritability and the comorbidity of attention deficit hyperactivity disorder with behavior disorders and executive function deficits: a preliminary investigation Developmental Neuropsychology 17 273-287
  • [6] Greenhill LL(1996)The robustness of test statistics to nonnormality and specification error in confirmatory factor analysis Psychological Methods 1 16-29
  • [7] Auerbach JG(2005)Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD? Journal of Child Psychology and Psychiatry 46 778-803
  • [8] Benjamin J(2007)An association between dopamine D4 receptor and transporter gene polymorphisms and personality traits, assessed using NEO-FFI in a Polish female population Personality and Individual Differences 43 531-540
  • [9] Faroy M(2003)A review of the biological bases of ADHD: what have we learned from imaging studies? Mental Retardation and Developmental Disabilities Research Reviews 9 184-195
  • [10] Geller V(2001)The relations of regulation and emotionality to children’s externalizing and internalizing problem behavior Child Development 72 1112-1134
12345678910