Neuroendocrine Carcinomas of the Larynx and Head and Neck: Challenges in Classification and Grading

被引：38

作者：

Perez-Ordoñez B. ^{[1
,2
]}

机构：

[1] Department of Anatomic Pathology, University Health Network, Toronto General Hospital, 200 Elizabeth Street, Toronto, M5G 2C4, ON

[2] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON

来源：

Head and Neck Pathology | 2018年 / 12卷 / 1期

关键词：

Atypical carcinoid tumor; Carcinoid tumor; Head and neck; Large cell carcinoma; Larynx; Neuroendocrine carcinoma; Small cell carcinoma;

D O I：

10.1007/s12105-018-0894-6

中图分类号：

学科分类号：

摘要：

Primary neuroendocrine carcinomas (NECs) of the larynx and head and neck are an uncommon and heterogeneous group of neoplasms categorized by the 2017 WHO Classification of Head and Neck Tumors as: (a) well-differentiated (WD-NEC), (b) moderately-differentiated (MD-NEC), and (c) poorly-differentiated (PD-NEC) with small cell and large cell types. The classification incorporates elements of differentiation and grading and closely correlates to the 5-year disease specific survival of 100, 52.8, 19.3 and 15.3% for each diagnostic category. These survival rates are based on historical data limited by the previous lack of standard pathologic diagnostic criteria. The classification has de-emphasized the use of the terms “carcinoid” and “atypical carcinoid” as diagnostic categories. The adoption of uniform pathologic criteria for the classification of NECs of the head and neck should enable the design of high quality studies in order to understand the molecular alterations of these neoplasms. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

引用

页码：1 / 8

页数：7

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