Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy

[41] Al-Sohaily S(2017)Assessing tumor-infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the international immunooncology biomarkers working group: part 1: assessing the host immune response, TILs in invasive breast carcinoma and ductal carcinoma in situ, metastatic tumor deposits and areas for further research Adv Anat Pathol 24 235-92

[42] Mladenova DN(2018)T-cell exhaustion signatures vary with tumor type and are severe in glioblastoma Clin Cancer Res 24 4175-158

[43] Pangon L(2011)Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients J Clin Invest 121 2350-59

[44] Kennedy CW(2020)Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects Mol Cancer 19 116-643

[45] Tu W(2017)An atlas of human regulatory T helper-like cells reveals features of Th2-like tregs that support a tumorigenic environment Cell Rep 20 757-16

[46] Luo M(2012)Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells Lung Cancer 75 95-996

[47] Wang Z(2015)Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma Cancer Immunol Immunother 64 419-541

[48] Yan W(2020)Characterizing the dysfunctional NK Cell: assessing the clinical relevance of exhaustion, anergy, and senescence Front Cell Infect Microbiol 10 49-645

[49] Xia Y(2013)Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer J Transl Med 11 262-243

[50] Deng H(2017)NK cell exhaustion Front Immunol 8 760-100

[41] Al-Sohaily S(2017)Assessing tumor-infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the international immunooncology biomarkers working group: part 1: assessing the host immune response, TILs in invasive breast carcinoma and ductal carcinoma in situ, metastatic tumor deposits and areas for further research Adv Anat Pathol 24 235-92

[42] Mladenova DN(2018)T-cell exhaustion signatures vary with tumor type and are severe in glioblastoma Clin Cancer Res 24 4175-158

[43] Pangon L(2011)Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients J Clin Invest 121 2350-59

[44] Kennedy CW(2020)Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects Mol Cancer 19 116-643

[45] Tu W(2017)An atlas of human regulatory T helper-like cells reveals features of Th2-like tregs that support a tumorigenic environment Cell Rep 20 757-16

[46] Luo M(2012)Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells Lung Cancer 75 95-996

[47] Wang Z(2015)Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma Cancer Immunol Immunother 64 419-541

[48] Yan W(2020)Characterizing the dysfunctional NK Cell: assessing the clinical relevance of exhaustion, anergy, and senescence Front Cell Infect Microbiol 10 49-645

[49] Xia Y(2013)Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer J Transl Med 11 262-243

[50] Deng H(2017)NK cell exhaustion Front Immunol 8 760-100