Chemistry and cytotoxic activities of polyketides produced by the mangrove endophytic fungus Phomopsis SP. ZSU-H76

被引：0

作者：

Zhongjing Huang

Zhiyong Guo

Ruiyun Yang

Xianhong Yin

Xiaoyan Li

Weiqiang Luo

Zhigang She

Yongcheng Lin

机构：

[1] Guangxi University for Nationalities,College of Chemistry and Ecology Engineering

[2] China Three Gorges University,College of Chemistry and Life Science

[3] Guangxi Normal University,College of Chemistry and Chemical Engineering

[4] Sun Yat-Sen (Zhongshan) University,College of Chemistry and Chemical Engineering

来源：

Chemistry of Natural Compounds | 2009年 / 45卷

关键词：

mangrove endophytic fungus; polyketide; metabolites; cytotoxicity; Phomopsis sp.;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A new polyketide, 2-(7′-hydroxyoxooctyl)-3-hydroxy-5-methoxybenzeneacetic acid ethyl ester (1), together with three known compounds dothiorelone A (2), B (3), and C (4) were isolated from the mangrove endophytic fungus Phomopsis sp. ZSU-H76 obtained from the South China Sea. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopic techniques. Primary bioassays showed that 1 exhibited cytotoxicity against HEp-2 and HepG2 cells with IC50 values of 25 and 30 μg/mL, respectively.

引用

页码：625 / 628

页数：3