Chemistry and cytotoxic activities of polyketides produced by the mangrove endophytic fungus Phomopsis SP. ZSU-H76

被引：0
作者：
Zhongjing Huang
Zhiyong Guo
Ruiyun Yang
Xianhong Yin
Xiaoyan Li
Weiqiang Luo
Zhigang She
Yongcheng Lin
机构：
[1] Guangxi University for Nationalities,College of Chemistry and Ecology Engineering
[2] China Three Gorges University,College of Chemistry and Life Science
[3] Guangxi Normal University,College of Chemistry and Chemical Engineering
[4] Sun Yat-Sen (Zhongshan) University,College of Chemistry and Chemical Engineering
来源：
Chemistry of Natural Compounds | 2009年 / 45卷
关键词：
mangrove endophytic fungus; polyketide; metabolites; cytotoxicity; Phomopsis sp.;
D O I：
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中图分类号：
学科分类号：
摘要：
A new polyketide, 2-(7′-hydroxyoxooctyl)-3-hydroxy-5-methoxybenzeneacetic acid ethyl ester (1), together with three known compounds dothiorelone A (2), B (3), and C (4) were isolated from the mangrove endophytic fungus Phomopsis sp. ZSU-H76 obtained from the South China Sea. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopic techniques. Primary bioassays showed that 1 exhibited cytotoxicity against HEp-2 and HepG2 cells with IC50 values of 25 and 30 μg/mL, respectively.
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页码：625 / 628
页数：3
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