Vitamin D Status in Mothers and Their Newborns and Its Association with Pregnancy Outcomes: Experience from a Tertiary Care Center in Northern India

被引：19

作者：

Arora S. ^{[1
]}

Goel P. ^{[1
]}

Chawla D. ^{[2
]}

Huria A. ^{[1
]}

Arya A. ^{[2
]}

机构：

[1] Department of Obstetrics and Gynaecology, D Block Level IV GMCH Sector 32, Chandigarh

[2] Department of Pediatrics, D Block Level IV GMCH Sector 32, Chandigarh

来源：

The Journal of Obstetrics and Gynecology of India | 2018年 / 68卷 / 5期

关键词：

Hypovitaminosis D; Newborn; Pregnancy outcomes;

D O I：

10.1007/s13224-017-1067-3

中图分类号：

学科分类号：

摘要：

Objective: Study was planned to know vitamin D status in mothers and their newborns and effect of vitamin D deficiency on pregnancy outcome. Study design: Two hundred consecutive pregnant women with singleton pregnancy admitted to the labor ward of a tertiary care center were recruited for the study. Maternal and cord blood samples were taken and analyzed for 25(OH) D level. Maternal and fetal outcomes were studied. Results: High prevalence of hypovitaminosis D was found among pregnant women. Eighty-six percentage had vitamin D deficiency, 9.5% had insufficiency, and only 4.5% had sufficient vitamin D level. Women with preeclampsia had statistically significant vitamin D deficiency and insufficiency as compared to patients who had normal blood pressure levels (p = 0.04). Cesarean section rate was significantly higher in patients with vitamin D deficiency and insufficiency compared to sufficient group (p = 0.004). Cord blood 25(OH) D levels strongly correlated with maternal serum 25 (OH) D levels (p = 0.001, correlation coefficient r = 0.84). Conclusions: This study showed a very high prevalence of hypovitaminosis D among pregnant women and excellent correlation between maternal and fetal 25(OH) D levels. Hypovitaminosis D was associated with preeclampsia, increased Cesarean rate, and low birth weight babies. © 2017, Federation of Obstetric & Gynecological Societies of India.

引用

页码：389 / 393

页数：4

共 21 条

[1]

Sachan A., Gupta R., Das V., Et al., High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India, Am J Clin Nutr, 81, pp. 1060-1064, (2005)

[2]

Jain V., Gupta N., Kalaivani M., Et al., Vitamin D deficiency in healthy breastfed term infants at 3 months & their mothers in India: Seasonal variation & determinants, Indian J Med Res, 3, pp. 267-273, (2011)

[3]

Marwaha R.K., Tandon N., Chopra S., Et al., Vitamin D status in pregnant Indian women across trimesters and different seasons and its correlation with neonatal serum 25-hydroxyvitamin D levels, Br J Nutr, 106, pp. 1383-1389, (2011)

[4]

Committee A.C.O.G., Vitamin D: screening and supplementation during pregnancy, Obstet Gynecol, 118, pp. 197-198, (2011)

[5]

Lips P., Vitamin D physiology, Prog Biophys Mol Biol, 92, pp. 4-8, (2006)

[6]

Dietary reference intakes for calcium and vitamin D, (2011)

[7]

Zhila M., Arash H.N., Ali R.S., Et al., Vitamin D status in mothers and their newborns in Iran, BMC Pregnancy Childbirth, 7, pp. 1-7, (2007)

[8]

Sahu M., Bhatia V., Agarwal A., Et al., Vitamin D deficiency in rural girls and pregnant women despite abundant sunshine in northern India, Clin Endocrinol, 70, (2009)

[9]

Bodnar L.M., Catov J.M., Simhan H.N., Maternal vitamin D deficiency increases the risk of preeclampsia, J Clin Endocrinol Metab, 92, pp. 3517-3522, (2007)

[10]

Baker A.M., Haeri S., Camargo C.A., A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia, J Clin Endocrinol Metab, 95, pp. 5105-5109, (2010)

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