Knock-Down of the 37-kDa/67-kDa Laminin Receptor in Mouse Brain by Transgenic Expression of Specific Antisense LRP RNA

被引：0
作者：
Christoph Leucht
Karen Vana
Ingrid Renner-Müller
Dominique Dormont
Corinne Ida Lasmézas
Eckhard Wolf
Stefan Weiss
机构：
[1] Laboratorium für Molekulare Biologie Genzentrum Institut für Biochemie der LMU München,CEA, Laboratory for Prion Pathogenesis
[2] Genzentrum Institut für Molekulare Tierzucht,undefined
[3] Service de Neurovirologie DRM/DSV,undefined
来源：
Transgenic Research | 2004年 / 13卷
关键词：
antisense RNA; laminin receptor; LRP/LR; neuron-specific enolase (NSE); prion; PrP;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The 37-kDa/67-kDa laminin receptor (LRP/LR) plays a major role in the propagation of PrPSc, the abnormal form of the prion protein. In order to ablate the expression of LRP/LR in mouse brain we generated transgenic mice ectopically expressing antisense LRP RNA in the brain under control of the neuron-specific enolase (NSE) promoter. Hemizygous transgenic mice TgN(NSEasLRP)2 showed a significant reduction of LRP/LR protein levels in hippocampal and cerebellar brain regions. These mice might act as powerful tools to investigate the role of the laminin receptor in scrapie pathogenesis.
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页码：81 / 85
页数：4
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