Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

被引：0

作者：

Usman A Khan

Li Liu

Frank A Provenzano

Diego E Berman

Caterina P Profaci

Richard Sloan

Richard Mayeux

Karen E Duff

Scott A Small

机构：

[1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain,Department of Neurology

[2] Columbia University College of Physicians and Surgeons,Department of Pathology

[3] Columbia University College of Physicians and Surgeons,Department of Psychiatry

[4] Program in Neural and Behavioral Science,Department of Radiology

[5] State University of New York Downstate Medical Center,undefined

[6] Columbia University College of Physicians and Surgeons,undefined

[7] Columbia University College of Physicians and Surgeons,undefined

[8] Columbia University College of Physicians and Surgeons,undefined

来源：

Nature Neuroscience | 2014年 / 17卷

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D O I：

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学科分类号：

摘要：

In the brains of Alzheimer's disease patients, the entorhinal cortex is known to show signs of early pathology. In this study, Khan et al. performed cerebral blood volume imaging of patients with preclinical Alzheimer's disease and mouse models of disease. Their results pinpoint the subregion in the entorhinal cortex most sensitive to the disease, and show how amyloid and tau interact in driving dysfunction and how dysfunction spreads to distal cortical regions.

引用

页码：304 / 311

页数：7

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