Synthesis of new oxadiazole derivatives as anti-inflammatory, analgesic, and antimicrobial agents

被引:0
作者
G. C. Ramaprasad
Balakrishna Kalluraya
B. Sunil Kumar
Sahana Mallya
机构
[1] Mangalore University,Department of Studies in Chemistry
[2] N.E.T. Pharmacy College,Department of Pharmaceutical Chemistry
[3] Syngene International Ltd.,undefined
来源
Medicinal Chemistry Research | 2013年 / 22卷
关键词
Oxadiazole; Oxadiazolone; Antibacterial; Antifungal; Anti-inflammatory; Analgesic;
D O I
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中图分类号
学科分类号
摘要
In search of pharmalogically active molecules in the class of oxadiazoles, the present article deals with the synthesis of 5-(5′-fluoro-2′-methoxybiphenyl-3-yl)-1,3,4-oxadiazol-2(3H)-one 2 from its hydrazide analog 1. The compound 2 was regioselectively N-alkylated with alkyl halides and produced the compounds 3a–f. Compound 3f was further functionalized with substituted benzenesulfonyl chlorides to give compounds 3g–j. The synthesized compounds were characterized by elemental and spectral analysis. Newly synthesized compounds were tested for their in vivo anti-inflammatory, analgesic, and in vitro antimicrobial activities. The compounds 3a–c were found to have promising anti-inflammatory and analgesic activities. Compounds 3b, 3f, and 3g showed significant antibacterial and antifungal activities.
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页码:5381 / 5389
页数:8
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