Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

被引：0
|
作者：
Margarita Dominguez-Villar
Clare M Baecher-Allan
David A Hafler
机构：
[1] Yale School of Medicine,Departments of Neurology and Immunobiology
[2] Harvard Medical School,undefined
来源：
Nature Medicine | 2011年 / 17卷
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摘要：
In mice, T regulatory (Treg) cells show considerable phenotypic and functional plasticity. David Hafler and his colleagues report that the frequency of human Treg cells expressing IFN-γ is increased in the peripheral blood of individuals with multiple sclerosis. These Treg cells possess reduced suppressive activity, and in vitro studies suggest that IL-12 promotes the development of a T helper type 1–like phenotype.
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页码：673 / 675
页数：2
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