Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

被引：0

作者：

Margarita Dominguez-Villar

Clare M Baecher-Allan

David A Hafler

机构：

[1] Yale School of Medicine,Departments of Neurology and Immunobiology

[2] Harvard Medical School,undefined

来源：

Nature Medicine | 2011年 / 17卷

关键词：

D O I：

暂无

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学科分类号：

摘要：

In mice, T regulatory (Treg) cells show considerable phenotypic and functional plasticity. David Hafler and his colleagues report that the frequency of human Treg cells expressing IFN-γ is increased in the peripheral blood of individuals with multiple sclerosis. These Treg cells possess reduced suppressive activity, and in vitro studies suggest that IL-12 promotes the development of a T helper type 1–like phenotype.

引用

页码：673 / 675

页数：2

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